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J. Biol. Chem., Vol. 263, Issue 32, 16604-16609, 11, 1988
SL Lee, K Stewart and RH Goodman
The gene encoding the hypothalamic peptide thyrotropin releasing hormone
(TRH) was isolated from two rat genomic bacteriophage libraries. Southern
blot analysis indicates that the gene is present as a single copy in the
rat genome. The transcriptional unit is 2.6 kilobases in size and contains
three exons interrupted by two introns of approximately 750 and 450 base
pairs. Exon 1 encodes the 5'- untranslated region of the mRNA, exon 2
encodes the signal sequence and the majority of the amino-terminal peptide,
and exon 3 encodes the remainder of the amino-terminal peptide, five copies
of the TRH sequence, the carboxyl-terminal peptide, and the 3'-untranslated
region of the mRNA. The general structure of the TRH gene resembles that of
three other polypeptide hormone genes, preproopiomelanocortin,
preproenkephalin A, and preproenkephalin B. Further sequence analysis
revealed that characteristic promoter elements are present in the 5'-
flanking region of the TRH gene. In addition, sequence homologies with the
glucocorticoid receptor binding site, the GC box hexanucleotide, and a
portion of the flanking region of the thyroid stimulating hormone
beta-subunit gene were also identified. These upstream sequences may be
important for the regulation of TRH gene expression.
Structure of the gene encoding rat thyrotropin releasing hormone
Division of Molecular Medicine, New England Medical Center Hospitals, Boston, Massachusetts 02111.
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