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J. Biol. Chem., Vol. 263, Issue 35, 18816-18820, Dec, 1988
LB Smillie, K Golosinska and FC Reinach
cDNAs containing the complete coding sequences of four isoforms of troponin
T derived from 1-week-old chick skeletal muscle have been isolated and
sequenced. While the 5' and 3' untranslated regions and most of the coding
sequence were identical for each, dramatic differences were observed in the
NH2-terminal region corresponding to amino acid residues 10-37 of rabbit
skeletal troponin T. These sequence differences correspond to the
alternatively spliced but not mutually exclusive exons 4 to 8 of the rat
skeletal muscle troponin T gene. In addition, we observe a sequence
corresponding to an extra exon or exons (between 5 and 6) present in the
chicken skeletal muscle gene and not previously detected in the rat
skeletal or chicken cardiac genes. This sequence of 63 nucleotides consists
of an almost perfect repeat of 30 and 33 nucleotides and has previously
been shown to be represented as a protein variant in chicken skeletal
muscle. A difference is also present in one cDNA clone corresponding to the
alternatively spliced (mutually exclusive) exons 16 and 17 of the rat gene.
In the protein, this corresponds to a region implicated in the interaction
of troponin T with troponin C, tropomyosin, and perhaps troponin I and
F-actin.
Sequences of complete cDNAs encoding four variants of chicken skeletal muscle troponin T
Department of Biochemistry, University of Alberta, Edmonton, Canada.
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