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J. Biol. Chem., Vol. 263, Issue 5, 2111-2114, Feb, 1988
K Terazono, H Yamamoto, S Takasawa, K Shiga, Y Yonemura, Y Tochino and H Okamoto
Administration of poly(ADP-ribose) synthetase inhibitors such as
nicotinamide to 90% depancreatized rats induces regeneration of pancreatic
islets, thereby ameliorating the surgical diabetes (Yonemura, Y.,
Takashima, T., Miwa, K., Miyazaki, I., Yamamoto, H., and Okamoto, H. (1984)
Diabetes 33, 401-404). In screening the regenerating islet-derived cDNA
library, we came across a novel gene encoding a 165- amino acid protein.
The gene was expressed in regenerating islets but not in normal pancreatic
islets, insulinomas, or regenerating liver. In 90% depancreatized and
nicotinamide-injected rats, the expression of the gene was increased 1
month after the partial pancreatectomy and reached a peak 3 months after
the operation. The increase in expression of the gene was temporally
correlated with the increase in size of regenerating islets and the
decrease in urinary glucose level. The gene was also found to be activated
in hyperplastic islets of aurothioglucose-treated mice. Thus, the
expression of the gene in both regenerating and hyperplastic islets
suggests possible roles for this gene in replication, growth, and
maturation of islet beta-cells. We also found that a human pancreas-derived
cDNA library contained a homologue to the gene.
A novel gene activated in regenerating islets
Department of Biochemistry, Tohoku University School of Medicine, Miyagi, Japan.
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