| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
J. Biol. Chem., Vol. 263, Issue 8, 3550-3553, Mar, 1988
JP Merlie, D Fagan, J Mudd and P Needleman
An oligonucleotide probe was used to isolate a clone encoding prostaglandin
endoperoxide synthetase (cyclooxygenase, EC 1.14.99.1) from a sheep seminal
vesicle cDNA library. The protein predicted from nucleic acid sequence
contains 599 amino acids including a 23-amino acid signal sequence. Thus,
the mature cyclooxygenase deduced from the cDNA compares favorably in
molecular size to the 70-kDa protein determined by gel electrophoresis. A
putative transmembrane region and potential carbohydrate addition sites for
N-linked sugars can be inferred from the amino acid sequence.
Significantly, sequence similarities exist between cyclooxygenase,
myeloperoxidase, and several other heme-containing proteins. The putative
glycosylation sites, transmembrane domain, and sequence similarities with
functionally related enzymes have been incorporated into a model for the
topology of cyclooxygenase in the endoplasmic reticulum.
Isolation and characterization of the complementary DNA for sheep seminal vesicle prostaglandin endoperoxide synthase (cyclooxygenase)
Department of Pharmacology, Washington University School of Medicine, St. Louis, Missouri 63110.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  Q. Zhang, V. Collins, K. Chakrabarty, R. F. Wolf, N. Unno, D. Howe, J. C. Rose, and W. X. Wu Regulation of Membrane-Associated Prostaglandin E2 Synthase 1 in Pregnant Sheep Intrauterine Tissues by Glucocorticoid and Estradiol Endocrinology, August 1, 2006; 147(8): 3719 - 3726. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Qin, S.-P. Zhang, T. L. Reitz, J. M. Mei, and C. M. Flores Cloning, Expression, and Functional Characterization of Human Cyclooxygenase-1 Splicing Variants: Evidence for Intron 1 Retention J. Pharmacol. Exp. Ther., December 1, 2005; 315(3): 1298 - 1305. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Mollace, C. Muscoli, E. Masini, S. Cuzzocrea, and D. Salvemini Modulation of Prostaglandin Biosynthesis by Nitric Oxide and Nitric Oxide Donors Pharmacol. Rev., June 1, 2005; 57(2): 217 - 252. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Hall-Pogar, H. Zhang, B. Tian, and C. S. Lutz Alternative polyadenylation of cyclooxygenase-2 Nucleic Acids Res., May 4, 2005; 33(8): 2565 - 2579. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. R. Brown and R. N. DuBois COX-2: A Molecular Target for Colorectal Cancer Prevention J. Clin. Oncol., April 20, 2005; 23(12): 2840 - 2855. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Ray, M. E. Bisher, and L. W. Enquist Cyclooxygenase-1 and -2 Are Required for Production of Infectious Pseudorabies Virus J. Virol., December 1, 2004; 78(23): 12964 - 12974. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. L. Simmons, R. M. Botting, and T. Hla Cyclooxygenase Isozymes: The Biology of Prostaglandin Synthesis and Inhibition Pharmacol. Rev., September 1, 2004; 56(3): 387 - 437. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Sirois, K. Sayasith, K. A. Brown, A. E. Stock, N. Bouchard, and M. Dore Cyclooxygenase-2 and its role in ovulation: a 2004 account Hum. Reprod. Update, September 1, 2004; 10(5): 373 - 385. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. M. Gajraj Cyclooxygenase-2 Inhibitors Anesth. Analg., June 1, 2003; 96(6): 1720 - 1738. [Full Text] [PDF]
|
|
|
|
 |
|
 D. Wu, M. Marko, K. Claycombe, K. E. Paulson, and S. N. Meydani Ceramide-induced and Age-associated Increase in Macrophage COX-2 Expression Is Mediated through Up-regulation of NF-kappa B Activity J. Biol. Chem., March 21, 2003; 278(13): 10983 - 10992. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Yang, S. J. Forrest, N. Stine, Y. Endo, A. Pasumarthy, H. Castrop, S. Aller, J. N. Forrest Jr., J. Schnermann, and J. Briggs Cyclooxygenase cloning in dogfish shark, Squalus acanthias, and its role in rectal gland Cl secretion Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2002; 283(3): R631 - R637. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. E. Daniels, S. Talwalker, S. Torri, M. C. Snabes, D. P. Recker, and K. M. Verburg Valdecoxib, a Cyclooxygenase-2-Specific Inhibitor, Is Effective in Treating Primary Dysmenorrhea Obstet. Gynecol., August 1, 2002; 100(2): 350 - 358. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. M. Prescott and H. J. Yost The COXes of Danio: From mechanistic model to experimental therapeutics PNAS, July 9, 2002; 99(14): 9084 - 9086. [Full Text] [PDF]
|
|
|
|
 |
|
 D. HWANG Modulation of the expression of cyclooxygenase-2 by fatty acids mediated through Toll-like receptor 4-derived signaling pathways FASEB J, December 1, 2001; 15(14): 2556 - 2564. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. S. Baek, J. W. Kim, J. H. Lee, H. J. Kwon, N. D. Kim, H. S. Kang, M. A. Yoo, B. P. Yu, and H. Y. Chung Age-Related Increase of Brain Cyclooxygenase Activity and Dietary Modulation of Oxidative Status J. Gerontol. A Biol. Sci. Med. Sci., October 1, 2001; 56(10): B426 - 431. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. X. Wu, X. H. Ma, N. Unno, and P. W. Nathanielsz In Vivo Evidence for Stimulation of Placental, Myometrial, and Endometrial Prostaglandin G/H Synthase 2 by Fetal Cortisol Replacement after Fetal Adrenalectomy Endocrinology, September 1, 2001; 142(9): 3857 - 3864. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. K. Hennan, J. Huang, T. D. Barrett, E. M. Driscoll, D. E. Willens, A. M. Park, L. J. Crofford, and B. R. Lucchesi Effects of Selective Cyclooxygenase-2 Inhibition on Vascular Responses and Thrombosis in Canine Coronary Arteries Circulation, August 14, 2001; 104(7): 820 - 825. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. W. Kim, B. S. Baek, Y. K. Kim, J. T. Herlihy, Y. Ikeno, B. P. Yu, and H. Y. Chung Gene Expression of Cyclooxygenase in the Aging Heart J. Gerontol. A Biol. Sci. Med. Sci., August 1, 2001; 56(8): B350 - 355. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A A Shah, B Thjodleifsson, F E Murray, E Kay, M Barry, G Sigthorsson, H Gudjonsson, E Oddsson, A B Price, D J Fitzgerald, et al. Selective inhibition of COX-2 in humans is associated with less gastrointestinal injury: a comparison of nimesulide and naproxen Gut, March 1, 2001; 48(3): 339 - 346. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Liu, M. Antaya, A. K. Goff, D. Boerboom, D. W. Silversides, J. G. Lussier, and J. Sirois Molecular Characterization of Bovine Prostaglandin G/H Synthase-2 and Regulation in Uterine Stromal Cells Biol Reprod, March 1, 2001; 64(3): 983 - 991. [Abstract] [Full Text]
|
|
|
|
 |
|
 M. D. Boudreau, K. H. Sohn, S. H. Rhee, S. W. Lee, J. D. Hunt, and D. H. Hwang Suppression of Tumor Cell Growth Both in Nude Mice and in Culture by n-3 Polyunsaturated Fatty Acids: Mediation through Cyclooxygenase-independent Pathways Cancer Res., February 1, 2001; 61(4): 1386 - 1391. [Abstract] [Full Text]
|
|
|
|
 |
|
 S. K. Paulson, J. Y. Zhang, A. P. Breau, J. D. Hribar, N. W. K. Liu, S. M. Jessen, Y. M. Lawal, J. N. Cogburn, C. J. Gresk, C. S. Markos, et al. Pharmacokinetics, Tissue Distribution, Metabolism, and Excretion of Celecoxib in Rats Drug Metab. Dispos., May 1, 2000; 28(5): 514 - 521. [Abstract] [Full Text]
|
|
|
|
|
|
T. J. Fiedler, C. A. Davey, and R. E. Fenna X-ray Crystal Structure and Characterization of Halide-binding Sites of Human Myeloperoxidase at 1.8 A Resolution J. Biol. Chem., April 14, 2000; 275(16): 11964 - 11971. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. K. Paulson, J. D. Hribar, N. W. K. Liu, E. Hajdu, R. H. Bible Jr., A. Piergies, and A. Karim Metabolism and Excretion of [14C]Celecoxib in Healthy Male Volunteers Drug Metab. Dispos., March 1, 2000; 28(3): 308 - 314. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 U. Schonbeck, G. K. Sukhova, P. Graber, S. Coulter, and P. Libby Augmented Expression of Cyclooxygenase-2 in Human Atherosclerotic Lesions Am. J. Pathol., October 1, 1999; 155(4): 1281 - 1291. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Yang, J. B. Schnermann, and J. P. Briggs Regulation of cyclooxygenase-2 expression in renal medulla by tonicity in vivo and in vitro Am J Physiol Renal Physiol, July 1, 1999; 277(1): F1 - F9. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Yang, D. Sun, Y. G. Huang, A. Smart, J. P. Briggs, and J. B. Schnermann Differential regulation of COX-2 expression in the kidney by lipopolysaccharide: role of CD14 Am J Physiol Renal Physiol, July 1, 1999; 277(1): F10 - F16. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. S. Jun, Z. Chen, M. C. Pace, and P. W. Shaul Glucocorticoids Downregulate Cyclooxygenase-1 Gene Expression and Prostacyclin Synthesis in Fetal Pulmonary Artery Endothelium Circ. Res., February 5, 1999; 84(2): 193 - 200. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. W. Shaul, M. C. Pace, Z. Chen, and T. S. Brannon Developmental Changes in Prostacyclin Synthesis Are Conserved in Cultured Pulmonary Endothelium and Vascular Smooth Muscle Am. J. Respir. Cell Mol. Biol., January 1, 1999; 20(1): 113 - 121. [Abstract] [Full Text]
|
|
|
|
|
|
Y. Li, T. Smith, S. Grabski, and D. L. DeWitt The Membrane Association Sequences of the Prostaglandin Endoperoxide Synthases-1 and -2 Isozymes J. Biol. Chem., November 6, 1998; 273(45): 29830 - 29837. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Mikuni, M. Pall, C.M. Peterson, C.A. Peterson, P. Hellberg, M. Brännström, J.S. Richards, and L. Hedin The Selective Prostaglandin Endoperoxide Synthase-2 Inhibitor, NS-398, Reduces Prostaglandin Production and Ovulation In Vivo and In Vitro in the Rat Biol Reprod, November 1, 1998; 59(5): 1077 - 1083. [Abstract] [Full Text]
|
|
|
|
 |
|
 M. M. Taketo Cyclooxygenase-2 Inhibitors in Tumorigenesis (Part I) J Natl Cancer Inst, October 21, 1998; 90(20): 1529 - 1536. [Abstract] [PDF]
|
|
|
|
|
|
D. Boerboom and J. Sirois Molecular Characterization of Equine Prostaglandin G/H Synthase-2 and Regulation of Its Messenger Ribonucleic Acid in Preovulatory Follicles Endocrinology, April 1, 1998; 139(4): 1662 - 1670. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Yallampalli, Y.-L. Dong, P. R. Gangula, and L. Fang Role and Regulation of Nitric Oxide in the Uterus During Pregnancy and Parturition Reproductive Sciences, March 1, 1998; 5(2): 58 - 67. [Abstract] [PDF]
|
|
|
|
|
|
T. Yang, I. Singh, H. Pham, D. Sun, A. Smart, J. B. Schnermann, and J. P. Briggs Regulation of cyclooxygenase expression in the kidney by dietary salt intake Am J Physiol Renal Physiol, March 1, 1998; 274(3): F481 - F489. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Vinals, J. Martinez-Gonzalez, J. J. Badimon, and L. Badimon HDL-Induced Prostacyclin Release in Smooth Muscle Cells Is Dependent on Cyclooxygenase-2 (Cox-2) Arterioscler. Thromb. Vasc. Biol., December 1, 1997; 17(12): 3481 - 3488. [Abstract] [Full Text]
|
|
|
|
|
|
E. Asselin, P. Drolet, and M. A. Fortier Cellular Mechanisms Involved during Oxytocin-Induced Prostaglandin F2{alpha} Production in Endometrial Epithelial Cells in Vitro: Role of Cyclooxygenase-2 Endocrinology, November 1, 1997; 138(11): 4798 - 4805. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Sirois and M. Dore The Late Induction of Prostaglandin G/H Synthase-2 in Equine Preovulatory Follicles Supports Its Role as a Determinant of the Ovulatory Process Endocrinology, October 1, 1997; 138(10): 4427 - 4434. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. X. Wu, X. H. Ma, Q. Zhang, L. Buchwalder, and P. W. Nathanielsz Regulation of Prostaglandin Endoperoxide H Synthase 1 and 2 by Estradiol and Progesterone in Nonpregnant Ovine Myometrium and Endometrium in Vivo Endocrinology, September 1, 1997; 138(9): 4005 - 4012. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Charpigny, P. Reinaud, J.-P. Tamby, C. Creminon, J. Martal, J. Maclouf, and M. Guillomot Expression of Cyclooxygenase-1 and -2 in Ovine Endometrium During the Estrous Cycle and Early Pregnancy Endocrinology, May 1, 1997; 138(5): 2163 - 2171. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Yamada, H. Niki, M. Yamashita, S. Mue, and K. Ohuchi Prostaglandin E2 Production Dependent upon Cyclooxygenase-1 and Cyclooxygenase-2 and Its Contradictory Modulation by Auranofin in Rat Peritoneal Macrophages J. Pharmacol. Exp. Ther., May 1, 1997; 281(2): 1005 - 1012. [Abstract] [Full Text]
|
|
|
|
|
|
E. C.J.M. de Vet, A. W.M. Zomer, G. J.H.T.J. Lahaut, and H. van den Bosch Polymerase Chain Reaction-based Cloning of Alkyl-dihydroxyacetonephosphate Synthase Complementary DNA from Guinea Pig Liver J. Biol. Chem., January 10, 1997; 272(2): 798 - 803. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. E. Bracken, W. Elger, I. Jantke, A. Nanninga, and B. Gellersen Cloning of Guinea Pig Cyclooxygenase-2 and 15-Hydroxyprostaglandin Dehydrogenase Complementary Deoxyribonucleic Acids: Steroid-Modulated Gene Expression Correlates to Prostaglandin F2{alpha} Secretion in Cultured Endometrial Cells Endocrinology, January 1, 1997; 138(1): 237 - 247. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. K. Morris and J. S. Richards An E-box Region within the Prostaglandin Endoperoxide Synthase-2 (PGS-2) Promoter Is Required for Transcription in Rat Ovarian Granulosa Cells J. Biol. Chem., July 12, 1996; 271(28): 16633 - 16643. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. K. Gierse, J. J. McDonald, S. D. Hauser, S. H. Rangwala, C. M. Koboldt, and K. Seibert A Single Amino Acid Difference between Cyclooxygenase-1 (COX-1) and -2(COX-2) Reverses the Selectivity of COX-2 Specific Inhibitors J. Biol. Chem., June 28, 1996; 271(26): 15810 - 15814. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. C. Otto and W. L. Smith J. Biol. Chem., April 26, 1996; 271(17): 9906 - 9910. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. K. Bhattacharyya, M. Lecomte, C. J. Rieke, R. M. Garavito, and W. L. Smith Involvement of Arginine 120, Glutamate 524, and Tyrosine 355 in the Binding of Arachidonate and 2-Phenylpropionic Acid Inhibitors to the Cyclooxygenase Active Site of Ovine Prostaglandin Endoperoxide H Synthase-1 J. Biol. Chem., January 26, 1996; 271(4): 2179 - 2184. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Bayle, D. Weeks, and G. Sachs The Membrane Topology of the Rat Sarcoplasmic and Endoplasmic Reticulum Calcium ATPases by in Vitro Translation Scanning J. Biol. Chem., October 27, 1995; 270(43): 25678 - 25684. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Laneuville, D. K. Breuer, N. Xu, Z. H. Huang, D. A. Gage, J. T. Watson, M. Lagarde, D. L. DeWitt, and W. L. Smith Fatty Acid Substrate Specificities of Human Prostaglandin-endoperoxide H Synthase-1 and -2 J. Biol. Chem., August 18, 1995; 270(33): 19330 - 19336. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Glover, T. Bayburt, M. Jonas, E. Chi, and M. H. Gelb Translocation of the 85-kDa Phospholipase A[IMAGE] from Cytosol to the Nuclear Envelope in Rat Basophilic Leukemia Cells Stimulated with Calcium Ionophore or IgE/Antigen J. Biol. Chem., June 23, 1995; 270(25): 15359 - 15367. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Ge, H. Hughes, D. C. Junquero, K. K. Wu, P. M. Vanhoutte, and C. M. Boulanger Endothelium-Dependent Contractions Are Associated With Both Augmented Expressionof Prostaglandin H Synthase-1 and Hypersensitivity to Prostaglandin H2in the SHR Aorta Circ. Res., June 1, 1995; 76(6): 1003 - 1010. [Abstract] [Full Text]
|
|
|
|
|
|
P. Chanmugam, L. Feng, S. Liou, B. C. Jang, M. Boudreau, G. Yu, J. H. Lee, H. J. Kwon, T. Beppu, M. Yoshida, et al. Radicicol, a Protein Tyrosine Kinase Inhibitor, Suppresses the Expression of Mitogen-inducible Cyclooxygenase in Macrophages Stimulated with Lipopolysaccharide and in Experimental Glomerulonephritis J. Biol. Chem., March 10, 1995; 270(10): 5418 - 5426. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. H. Paik, J. H. Ju, J. Y. Lee, M. D. Boudreau, and D. H. Hwang Two Opposing Effects of Non-steroidal Anti-inflammatory Drugs on the Expression of the Inducible Cyclooxygenase. MEDIATION THROUGH DIFFERENT SIGNALING PATHWAYS J. Biol. Chem., September 1, 2000; 275(36): 28173 - 28179. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Y. Lee, K. H. Sohn, S. H. Rhee, and D. Hwang Saturated Fatty Acids, but Not Unsaturated Fatty Acids, Induce the Expression of Cyclooxygenase-2 Mediated through Toll-like Receptor 4 J. Biol. Chem., May 11, 2001; 276(20): 16683 - 16689. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |
