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J. Biol. Chem., Vol. 264, Issue 13, 7092-7095, May, 1989
S Horowitz, N Dafni, DL Shapiro, BA Holm, RH Notter and DJ Quible
Exposure to high concentrations of oxygen can result in tissue damage,
particularly in the lung. Lung pathology induced by hyperoxia includes
changes in lung cell populations and morphology. Presumably, alterations in
gene expression underlie some of these cellular changes. In order to better
understand the molecular basis of these events, a cDNA library was
constructed from the mRNA of the lungs of a hyperoxia- exposed rabbit and
differentially screened for clones corresponding to hyperoxia-induced
messages. This approach has led to the isolation of four clones, three of
which are presented in this communication. One clone corresponds to a
message whose steady state levels were induced 6- fold and encodes the
tissue inhibitor of metalloproteinases, a protein that plays a key role in
the regulation of connective tissue turnover in some cells and potentiates
erythroid development in others.
Hyperoxic exposure alters gene expression in the lung. Induction of the tissue inhibitor of metalloproteinases mRNA and other mRNAs
Department of Pediatrics (Neonatology), University of Rochester Medical Center, New York 14642.
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