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J. Biol. Chem., Vol. 264, Issue 25, 14613-14616, 09, 1989
K Saida, Y Mitsui and N Ishida
A new peptide family (endothelin (ET] consisting of three members in
mammals appears to be present in mice according to genomic Southern blot
analysis. Two ET-related genes were identified by cloning and sequence
analysis of a mouse genome. One encoded a peptide identical to porcine and
human vasoconstrictor peptide ET, and the other encoded a novel peptide
differing from ET in 3 amino acid residues, with 4 cysteines in the same
positions as in ET. This novel peptide was synthesized and confirmed to
have in vivo pressor activity similar to that of ET. Northern blot
analysis, however, indicated the gene of this novel peptide to be expressed
only in the intestine, and not in other tissues or cell lines, or
endothelial cells. Furthermore, the peptide evoked a strong contractile
response in the guinea pig ileum. This peptide may thus be reasonably
classified as a gastrointestinal peptide, vasoactive intestinal contractor.
A novel peptide, vasoactive intestinal contractor, of a new (endothelin) peptide family. Molecular cloning, expression, and biological activity
Fermentation Research Institute, Agency of Industrial Science and Technology, Ibaraki, Japan.
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