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J. Biol. Chem., Vol. 265, Issue 1, 1-4, Jan, 1990
JH Exton
Several mechanisms of agonist control of PC hydrolysis have been described:
control by G proteins, protein kinase C, Ca2+, and tyrosine kinases. The
relative importance of these mechanisms remains to be demonstrated. Another
major point is the physiological significance of PC hydrolysis. The
prolonged formation of DAG from PC may be important in cellular control
mechanisms that require long term activation of protein kinase C. The
functions of PA are presently unknown, but the rapid formation of high
concentrations of this lipid during stimulation by agonists strongly
suggests that it has signaling functions. It is obvious that much work
remains to define the physiological significance of agonist-stimulated PC
breakdown.
Signaling through phosphatidylcholine breakdown
Howard Hughes Medical Institute, Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232.
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