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J. Biol. Chem., Vol. 265, Issue 11, 5934-5937, Apr, 1990
BE Vogel, G Tarone, FG Giancotti, J Gailit and E Ruoslahti
The integrins are a family of heterodimeric cell surface receptors for
extracellular matrix molecules. An analysis of integrin subunits expressed
by a number of cell lines identified a novel heterodimer. The alpha subunit
of this integrin was immunologically and electrophoretically
indistinguishable from the vitronectin receptor alpha subunit (alpha v) and
the beta subunit was indistinguishable from beta 1. Affinity chromatography
experiments and cell adhesion assays indicated that this receptor complex
is a new fibronectin receptor. Its unexpected subunit composition
demonstrates the importance of the beta subunit in determining the ligand
specificity of integrins and suggests that the current integrin
classification scheme needs revision.
A novel fibronectin receptor with an unexpected subunit composition (alpha v beta 1)
Cancer Research Center, La Jolla Cancer Research Foundation, California 92037.
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