| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
J. Biol. Chem., Vol. 265, Issue 17, 9682-9687, 06, 1990
DM Stafforini, MR Elstad, TM McIntyre, GA Zimmerman and SM Prescott
When monocytes mature to macrophages, their ability to accumulate the
pro-inflammatory lipid autacoid, platelet-activating factor (PAF), is
markedly decreased (Elstad, M. R. Stafforini, D. M., McIntyre, T. M.,
Prescott, S. M., and Zimmerman, G. A. (1989) J. Biol. Chem. 264, 8467-
8470) in conjunction with a 260-fold increase in the activity of
intracellular PAF acetylhydrolase (PAF-AH). We now demonstrate that
macrophages also secrete PAF-AH and that the secreted enzyme is
biochemically and immunologically identical to the human plasma PAF-AH. It
is sensitive to the same active-site-directed inhibitors, has the same
electrophoretic mobility, is associated with lipoprotein particles, and
transfers between low density lipoprotein and high density lipoprotein in a
pH-dependent manner like the plasma PAF-AH. In addition, both activities
hydrolyze oxidatively fragmented phospholipids and PAF. These data indicate
that macrophages are a cellular source of the plasma PAF-AH. Thus,
macrophages secrete an enzyme that inactivates lipid mediators at sites of
inflammation and in plasma. These changes during the maturation of
monocytes to macrophages may serve to limit the acute inflammatory
response.
Human macrophages secret platelet-activating factor acetylhydrolase
Nora Ecctes Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, Utah 84112.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  A. A. Gardner, E. C. Reichert, M. K. Topham, and D. M. Stafforini Identification of a Domain That Mediates Association of Platelet-activating Factor Acetylhydrolase with High Density Lipoprotein J. Biol. Chem., June 20, 2008; 283(25): 17099 - 17106. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Mannheim, J. Herrmann, D. Versari, M. Gossl, F. B. Meyer, J. P. McConnell, L. O. Lerman, and A. Lerman Enhanced Expression of Lp-PLA2 and Lysophosphatidylcholine in Symptomatic Carotid Atherosclerotic Plaques Stroke, May 1, 2008; 39(5): 1448 - 1455. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Vadas, M. Gold, B. Perelman, G. M. Liss, G. Lack, T. Blyth, F. E. R. Simons, K. J. Simons, D. Cass, and J. Yeung Platelet-Activating Factor, PAF Acetylhydrolase, and Severe Anaphylaxis N. Engl. J. Med., January 3, 2008; 358(1): 28 - 35. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Chen, L. Yang, J. M. Foulks, A. S. Weyrich, G. K. Marathe, and T. M. McIntyre Intracellular PAF catabolism by PAF acetylhydrolase counteracts continual PAF synthesis J. Lipid Res., November 1, 2007; 48(11): 2365 - 2376. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. G. Saougos, A. P. Tambaki, M. Kalogirou, M. Kostapanos, I. F. Gazi, R. L. Wolfert, M. Elisaf, and A. D. Tselepis Differential Effect of Hypolipidemic Drugs on Lipoprotein-Associated Phospholipase A2 Arterioscler. Thromb. Vasc. Biol., October 1, 2007; 27(10): 2236 - 2243. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. N. MacRitchie, A. A. Gardner, S. M. Prescott, and D. M. Stafforini Molecular basis for susceptibility of plasma platelet-activating factor acetylhydrolase to oxidative inactivation FASEB J, April 1, 2007; 21(4): 1164 - 1176. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. D. Kolodgie, A. P. Burke, K. S. Skorija, E. Ladich, R. Kutys, A. T. Makuria, and R. Virmani Lipoprotein-Associated Phospholipase A2 Protein Expression in the Natural Progression of Human Coronary Atherosclerosis Arterioscler. Thromb. Vasc. Biol., November 1, 2006; 26(11): 2523 - 2529. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. V. Mitsios, M. P. Vini, D. Stengel, E. Ninio, and A. D. Tselepis Human Platelets Secrete the Plasma Type of Platelet-Activating Factor Acetylhydrolase Primarily Associated With Microparticles Arterioscler. Thromb. Vasc. Biol., August 1, 2006; 26(8): 1907 - 1913. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Koenig, D. Twardella, H. Brenner, and D. Rothenbacher Lipoprotein-Associated Phospholipase A2 Predicts Future Cardiovascular Events in Patients With Coronary Heart Disease Independently of Traditional Risk Factors, Markers of Inflammation, Renal Function, and Hemodynamic Stress Arterioscler. Thromb. Vasc. Biol., July 1, 2006; 26(7): 1586 - 1593. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. C. Papavasiliou, C. Gouva, K. C. Siamopoulos, and A. D. Tselepis PAF-acetylhydrolase activity in plasma of patients with chronic kidney disease. Effect of long-term therapy with erythropoietin Nephrol. Dial. Transplant., May 1, 2006; 21(5): 1270 - 1277. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. O'Donoghue, D. A. Morrow, M. S. Sabatine, S. A. Murphy, C. H. McCabe, C. P. Cannon, and E. Braunwald Lipoprotein-Associated Phospholipase A2 and Its Association With Cardiovascular Outcomes in Patients With Acute Coronary Syndromes in the PROVE IT-TIMI 22 (PRavastatin Or atorVastatin Evaluation and Infection Therapy-Thrombolysis In Myocardial Infarction) Trial Circulation, April 11, 2006; 113(14): 1745 - 1752. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. H. Yang, J. P. McConnell, R. J. Lennon, G. W. Barsness, G. Pumper, S. J. Hartman, C. S. Rihal, L. O. Lerman, and A. Lerman Lipoprotein-Associated Phospholipase A2 Is an Independent Marker for Coronary Endothelial Dysfunction in Humans Arterioscler. Thromb. Vasc. Biol., January 1, 2006; 26(1): 106 - 111. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Koenig, N. Khuseyinova, H. Lowel, G. Trischler, and C. Meisinger Lipoprotein-Associated Phospholipase A2 Adds to Risk Prediction of Incident Coronary Events by C-Reactive Protein in Apparently Healthy Middle-Aged Men From the General Population: Results From the 14-Year Follow-Up of a Large Cohort From Southern Germany Circulation, October 5, 2004; 110(14): 1903 - 1908. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. J. Tonks, A. Tonks, R. H. K. Morris, K. P. Jones, and S. K. Jackson Regulation of platelet-activating factor synthesis in human monocytes by dipalmitoyl phosphatidylcholine J. Leukoc. Biol., July 1, 2003; 74(1): 95 - 101. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Tsimihodimos, A. Kakafika, A. P. Tambaki, E. Bairaktari, M. J. Chapman, M. Elisaf, and A. D. Tselepis Fenofibrate induces HDL-associated PAF-AH but attenuates enzyme activity associated with apoB-containing lipoproteins J. Lipid Res., May 1, 2003; 44(5): 927 - 934. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C.-H. Chen, T. Jiang, J.-H. Yang, W. Jiang, J. Lu, G. K. Marathe, H. J. Pownall, C. M. Ballantyne, T. M. McIntyre, P. D. Henry, et al. Low-Density Lipoprotein in Hypercholesterolemic Human Plasma Induces Vascular Endothelial Cell Apoptosis by Inhibiting Fibroblast Growth Factor 2 Transcription Circulation, April 29, 2003; 107(16): 2102 - 2108. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. M. Forte, G. Subbanagounder, J. A. Berliner, P. J. Blanche, A. O. Clermont, Z. Jia, M. N. Oda, R. M. Krauss, and J. K. Bielicki Altered activities of anti-atherogenic enzymes LCAT, paraoxonase, and platelet-activating factor acetylhydrolase in atherosclerosis-susceptible mice J. Lipid Res., March 1, 2002; 43(3): 477 - 485. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Tsimihodimos, S.-A. P. Karabina, A. P. Tambaki, E. Bairaktari, G. Miltiadous, J. A. Goudevenos, M. A. Cariolou, M. J. Chapman, A. D. Tselepis, and M. Elisaf Altered distribution of platelet-activating factor- acetylhydrolase activity between LDL and HDL as a function of the severity of hypercholesterolemia J. Lipid Res., February 1, 2002; 43(2): 256 - 263. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Tsimihodimos, S.-A. P. Karabina, A. P. Tambaki, E. Bairaktari, J. A. Goudevenos, M. J. Chapman, M. Elisaf, and A. D. Tselepis Atorvastatin Preferentially Reduces LDL-Associated Platelet-Activating Factor Acetylhydrolase Activity in Dyslipidemias of Type IIA and Type IIB Arterioscler. Thromb. Vasc. Biol., February 1, 2002; 22(2): 306 - 311. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. D. Tselepis, S.-A. P. Karabina, D. Stengel, R. Piedagnel, M. J. Chapman, and E. Ninio N-linked glycosylation of macrophage-derived PAF-AH is a major determinant of enzyme association with plasma HDL J. Lipid Res., October 1, 2001; 42(10): 1645 - 1654. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Hakkinen, J. S. Luoma, M. O. Hiltunen, C. H. Macphee, K. J. Milliner, L. Patel, S. Q. Rice, D. G. Tew, K. Karkola, and S. Yla-Herttuala Lipoprotein-Associated Phospholipase A2, Platelet-Activating Factor Acetylhydrolase, Is Expressed by Macrophages in Human and Rabbit Atherosclerotic Lesions Arterioscler. Thromb. Vasc. Biol., December 1, 1999; 19(12): 2909 - 2917. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Kawano, H. Narahara, and J. M. Johnston Inhibitory Effect of Interleukin-8 on the Secretion of Platelet-Activating Factor Acetylhydrolase by Human Decidual Macrophages Reproductive Sciences, November 1, 1999; 6(6): 328 - 332. [Abstract] [PDF]
|
|
|
|
 |
|
 R. A. Memon, J. Fuller, A. H. Moser, K. R. Feingold, and C. Grunfeld In vivo regulation of plasma platelet-activating factor acetylhydrolase during the acute phase response Am J Physiol Regulatory Integrative Comp Physiol, July 1, 1999; 277(1): R94 - R103. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Cao, D. M. Stafforini, G. A. Zimmerman, T. M. McIntyre, and S. M. Prescott Expression of Plasma Platelet-activating Factor Acetylhydrolase Is Transcriptionally Regulated by Mediators of Inflammation J. Biol. Chem., February 13, 1998; 273(7): 4012 - 4020. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. M. Howard, J. E. Miller, M. Miwa, and M. S. Olson Cell-specific Regulation of Expression of Plasma-type Platelet-activating Factor Acetylhydrolase in the Liver J. Biol. Chem., October 31, 1997; 272(44): 27543 - 27548. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Triggiani, V. De Marino, M. Sofia, S. Faraone, G. Ambrosio, L. Carrat, and G. Marone Characterization of Platelet-activating Factor Acetylhydrolase in Human Bronchoalveolar Lavage Am. J. Respir. Crit. Care Med., July 1, 1997; 156(1): 94 - 100. [Abstract] [Full Text]
|
|
|
|
 |
|
 R. Godiska, D. Chantry, C. J. Raport, S. Sozzani, P. Allavena, D. Leviten, A. Mantovani, and P. W. Gray Human Macrophage-derived Chemokine (MDC), a Novel Chemoattractant for Monocytes, Monocyte-derived Dendritic Cells, and Natural Killer Cells J. Exp. Med., May 5, 1997; 185(9): 1595 - 1604. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. W. Tjoelker, C. Eberhardt, J. Unger, H. Le Trong, G. A. Zimmerman, T. M. McIntyre, D. M. Stafforini, S. M. Prescott, and P. W. Gray Plasma Platelet-activating Factor Acetylhydrolase Is a Secreted Phospholipase A(2) with a Catalytic Triad J. Biol. Chem., October 27, 1995; 270(43): 25481 - 25487. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. D. Tselepis, C. Dentan, S.-A. P. Karabina, M. J. Chapman, and E. Ninio PAF-Degrading Acetylhydrolase Is Preferentially Associated With Dense LDL and VHDL-1 in Human Plasma : Catalytic Characteristics and Relation to the Monocyte-Derived Enzyme Arterioscler. Thromb. Vasc. Biol., October 1, 1995; 15(10): 1764 - 1773. [Abstract] [Full Text]
|
|
|
|
|
|
K. M. Howard and M. S. Olson The Expression and Localization of Plasma Platelet-activating Factor Acetylhydrolase in Endotoxemic Rats J. Biol. Chem., June 23, 2000; 275(26): 19891 - 19896. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |
