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J. Biol. Chem., Vol. 265, Issue 19, 10925-10928, Jul, 1990
AK Batta, G Salen, R Arora, S Shefer, M Batta and A Person
The effect of side chain conjugation on 7-dehydroxylation of bile acids has
been investigated. C24-bile acids and their glycine and taurine conjugates
and keto bile acids were incubated with pure strains of Eubacterium sp. VPI
12708. Bile acids of the 5 alpha- or 5 beta-series with a free terminal
carboxyl group and a 3 alpha, 7 alpha-dihydroxy system were very
effectively 7 alpha-dehydroxylated, whereas 7 beta- hydroxy bile acids
resisted 7-dehydroxylation. Oxo bile acids were metabolized at the oxygen
function also. Glycine- and taurine- conjugated bile acids were neither
deamidated nor 7-dehydroxylated by the bacteria. Thus, side chain
conjugation prevents 7-dehydroxylation of bile acids by Eubacterium sp. VPI
12708.
Side chain conjugation prevents bacterial 7-dehydroxylation of bile acids
Department of Medicine, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark 07103.
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