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J. Biol. Chem., Vol. 265, Issue 23, 13431-13434, 08, 1990

Translational discrimination of mRNAs coding for human insulin-like growth factor II

FC Nielsen, S Gammeltoft and J Christiansen
Department of Clinical Chemistry, Bispebjerg Hospital, Copenhagen NV, Denmark.

Sucrose gradient and Northern analyses were used to study the translational status of endogenous multiple mRNAs encoding the prepropeptide for human insulin-like growth factor II. The results showed that a minor 4.8-kilobase mRNA was exclusively engaged in the synthesis of the prepropeptide on membrane-bound polysomes, whereas a major 6.0-kilobase mRNA was present in a cytoplasmic particle which was stable in EDTA. We conclude that the translational discrimination between the mRNAs is dictated by their different 5'-untranslated regions.
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