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J. Biol. Chem., Vol. 265, Issue 27, 16116-16125, Sep, 1990
GF Morris and MB Mathews
The levels of the mRNA for the proliferating cell nuclear antigen (PCNA), a
DNA replication factor, increase upon growth stimulation of quiescent
cells. To study the transcriptional aspect of this response, we have cloned
a PCNA gene fragment from size-fractionated human placental DNA. This
fragment contains 1269 nucleotides upstream from the PCNA transcriptional
start site and includes an Alu sequence that is transcribed in vitro. The
PCNA genomic DNA promotes transcription of a linked heterologous reporter
gene in HeLa and 293 cells. Transient expression assays and in vitro
transcription analyses showed that 249 nucleotides of upstream sequence are
sufficient for full promoter activity in HeLa cells, whereas only 172
nucleotides are needed in 293 cells. Co-transfection with a plasmid
expressing the adenovirus E1 gene transactivates the PCNA promoter in HeLa
cells. An E1-responsive element maps in the 85-nucleotide region
immediately upstream of the site of transcription initiation.
Analysis of the proliferating cell nuclear antigen promoter and its response to adenovirus early region 1
Cold Spring Harbor Laboratory, New York 11724.
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