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J. Biol. Chem., Vol. 265, Issue 31, 18713-18716, Nov, 1990
S Hakomori
Glycosphingolipids (GSLs), or their modified catabolites, at the cell
surface modulate transmembrane signal transduction by influencing protein
kinases associated with growth factor receptors and protein kinase C. On
the other hand, the same or different GSLs at the cell surface interact in
highly specific fashion with other GSLs or with binding proteins, possibly
at the surface of adjacent interacting cells or in the extracellular
matrix. The GSL-GSL interaction apparently provides the basis for a
specific cell recognition system independent of the fibronectin/integrin or
surface lectin systems, occurring earlier during a cell recognition event.
Bifunctional role of glycosphingolipids. Modulators for transmembrane signaling and mediators for cellular interactions
Biomembrane Institute, Seattle, Washington.
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