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J. Biol. Chem., Vol. 265, Issue 33, 20065-20068, 11, 1990

Mapping of a retinoic acid-responsive element in the promoter region of the complement factor H gene

P Munoz-Canoves, DP Vik and BF Tack
Department of Immunology, Scripps Clinic and Research Foundation, La Jolla, California 92037.

Retinoic acid receptors are members of the steroid/thyroid hormone receptor superfamily. Pursuant to the discovery that dexamethasone increases complement factor H expression, we examined the effects of retinoic acid on this gene. Both H mRNA and protein levels are increased by retinoic acid in L cells. Using the luciferase reporter gene system we have identified a region of the H promoter required for the retinoic acid response. This region contains an imperfect palindrome of the TGACC motif, present in thyroid hormone and estrogen- responsive elements. We demonstrate specific binding of the retinoic acid receptor beta to this sequence of the H gene by DNA-protein gel retardation assay. Therefore, these studies extend the sphere of influence of the retinoids to complement, an intrinsic component of the humoral immune system.
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