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J. Biol. Chem., Vol. 265, Issue 4, 1919-1923, Feb, 1990
L Urbani and RD Simoni
Transport of newly synthesized cholesterol and vesicular stomatitis virus G
protein from the endoplasmic reticulum to the plasma membrane is
interrupted by incubation at 15 degrees C. Under this condition the newly
synthesized molecules accumulate in both the endoplasmic reticulum (ER) and
a subcellular vesicle fraction of low density called the lipid-rich vesicle
fraction. The material in the lipid-rich vesicle fraction appears to be a
post-ER intermediate in the transport process to the plasma membrane (PM).
Although both newly synthesized cholesterol and G protein accumulate in
this intermediate compartment at 15 degrees C, suggesting cotransport,
treatment with Brefeldin A does not affect cholesterol transport to the PM,
whereas it strongly inhibits G protein transport. We conclude that
cholesterol and G protein leave the ER in separate vesicles, the
cholesterol containing vesicles bypass the Golgi apparatus and proceed to
the PM, whereas G protein containing vesicles follow the well documented
Golgi route to the cell surface.
Cholesterol and vesicular stomatitis virus G protein take separate routes from the endoplasmic reticulum to the plasma membrane
Department of Biological Sciences, Stanford University, California 94305-5020.
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