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J. Biol. Chem., Vol. 265, Issue 7, 3595-3598, 03, 1990
I Komuro, T Kaida, Y Shibazaki, M Kurabayashi, Y Katoh, E Hoh, F Takaku and Y Yazaki
Recently cellular protooncogenes have been found to be induced as an early
response to pressure overload in cardiac hypertrophy. To examine whether
mechanical stimuli directly induce specific gene expression in the heart,
we cultured rat neonatal cardiocytes in elastic silicone dishes and
stretched these adherent cells. Myocyte stretching stimulated expression of
the protooncogene, c-fos, in a stretch length- dependent manner, followed
by an increase in amino acid incorporation into proteins. c-fos mRNA levels
were enhanced within 15 min by cardiocyte stretching, peaked at 30 min, and
declined to undetectable levels by 240 min. In the presence of
cycloheximide, a greater increase in c-fos mRNA was seen by stretching. The
transfected chloramphenicol acetyltransferase gene linked to upstream
sequences of the fos gene including its promoter was also activated by
stretching cardiac myocytes. These results suggest that mechanical loading
directly regulates gene transcription without the participation of humoral
factors in cardiocytes.
Stretching cardiac myocytes stimulates protooncogene expression
Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan.
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K. Harada, I. Komuro, Y. Zou, S. Kudoh, K. Kijima, H. Matsubara, T. Sugaya, K. Murakami, and Y. Yazaki Acute Pressure Overload Could Induce Hypertrophic Responses in the Heart of Angiotensin II Type 1a Knockout Mice Circ. Res., April 20, 1998; 82(7): 779 - 785. [Abstract] [Full Text] [PDF]
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