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J. Biol. Chem., Vol. 265, Issue 7, 3703-3707, 03, 1990
J Koppel, MC Boutterin, V Doye, H Peyro-Saint-Paul and A Sobel
Stathmin is a 19-kDa phosphoprotein presumably involved in regulations of
cell proliferation, differentiation, and functions as an intracellular
relay for extracellular signals activating diverse second messenger
pathways. Antisera prepared against the whole protein or against two
peptides (residues 15-27 and 134-149) recognized the two isoforms (alpha
and beta) of stathmin in their different phosphorylated states on
immunoblots. Also, the possible existence of a family of stathmin-related
proteins is suggested by the detection with some sera of proteins of 17,
21, and 60 kDa in brain. Stathmin and its diverse molecular forms were
detected in all mouse tissues tested, in varying concentrations. Depending
on the tissue, it is 2-100 times more abundant in the neonate than in the
adult. It is most abundant in brain at both developmental stages, the
protein levels being paralleled by the expression of the corresponding mRNA
as detected with a specific cDNA probe. Antibodies directed against the rat
protein also reacted with stathmin-like proteins in the brain of other
mammals, birds, reptiles, amphibians, and some fish species, and the
various isoforms could be recognized on immunoblots. In conclusion, our
results suggest that stathmin is most likely involved in two distinct types
of regulations: 1) "developmental" regulations, related to cell
proliferation, differentiation, and maturation, and 2) "functional"
regulations mostly at the adult stage, and typically in the nervous system.
In addition, stathmin is also phylogenetically well conserved at least in
vertebrates. Together, these observations support the proposed ubiquitous
nature and general importance of stathmin in biological regulations.
Developmental tissue expression and phylogenetic conservation of stathmin, a phosphoprotein associated with cell regulations
Institut National de la Sante et de la Recherche Medicale U 153, Centre National de la Recherche Scientifique URA 614, Paris, France.
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