JBC

HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Montpied, P.
Right arrow Articles by Paul, S. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Montpied, P.
Right arrow Articles by Paul, S. M.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

J. Biol. Chem., Vol. 266, Issue 10, 6011-6014, Apr, 1991

gamma-Aminobutyric acid (GABA) induces a receptor-mediated reduction in GABAA receptor alpha subunit messenger RNAs in embryonic chick neurons in culture

P Montpied, EI Ginns, BM Martin, D Roca, DH Farb and SM Paul
Section on Molecular Pharmacology, National Institute of Mental Health, Bethesda, Maryland 20892.

gamma-Aminobutyric acid (GABA), the major inhibitory neurotransmitter in brain, is known to interact with a subclass of receptors that activate a ligand-gated chloride ion channel. Exposure of cultured embryonic chick neurons to physiological concentrations of GABA results in a time-dependent down-regulation of these GABAA receptors. To delineate the cellular mechanism(s) responsible for agonist-induced down-regulation of GABAA receptors we quantified the levels of GABAA receptor alpha subunit messenger RNAs, which encode the subunit(s) containing agonist recognition site(s), and observed a marked reduction in alpha subunit mRNAs following exposure of embryonic chick neurons to GABA. Both the down-regulation of GABAA receptors and the reduction in alpha subunit mRNAs induced by GABA were completely antagonized by the specific GABAA receptor antagonist SR-95531. These data demonstrate the presence of an agonist-induced receptor-mediated mechanism for regulating the expression of receptor subunit-encoding mRNAs that may be involved in the development of tolerance to the pharmacological actions of drugs known to act via GABAA receptors.
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 J. Biol. Chem.Home page
Y. Hu, I. V. Lund, M. C. Gravielle, D. H. Farb, A. R. Brooks-Kayal, and S. J. Russek
Surface Expression of GABAA Receptors Is Transcriptionally Controlled by the Interplay of cAMP-response Element-binding Protein and Its Binding Partner Inducible cAMP Early Repressor
J. Biol. Chem., April 4, 2008; 283(14): 9328 - 9340.
[Abstract] [Full Text] [PDF]

Home page
 Arch Gen PsychiatryHome page
J. H. Krystal, J. Staley, G. Mason, I. L. Petrakis, J. Kaufman, R. A. Harris, J. Gelernter, and J. Lappalainen
{gamma}-Aminobutyric Acid Type A Receptors and Alcoholism: Intoxication, Dependence, Vulnerability, and Treatment.
Arch Gen Psychiatry, September 1, 2006; 63(9): 957 - 968.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. C. Gravielle, R. Faris, S. J. Russek, and D. H. Farb
GABA Induces Activity Dependent Delayed-onset Uncoupling of GABA/Benzodiazepine Site Interactions in Neocortical Neurons
J. Biol. Chem., June 3, 2005; 280(22): 20954 - 20960.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
D. W. Volk, J. N. Pierri, J.-M. Fritschy, S. Auh, A. R. Sampson, and D. A. Lewis
Reciprocal Alterations in Pre- and Postsynaptic Inhibitory Markers at Chandelier Cell Inputs to Pyramidal Neurons in Schizophrenia
Cereb Cortex, October 1, 2002; 12(10): 1063 - 1070.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
S. J. Russek, S. Bandyopadhyay, and D. H. Farb
An initiator element mediates autologous downregulation of the human type A gamma -aminobutyric acid receptor beta 1 subunit gene
PNAS, July 18, 2000; 97(15): 8600 - 8605.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
P. Follesa, M. Serra, E. Cagetti, M. G. Pisu, S. Porta, S. Floris, F. Massa, E. Sanna, and G. Biggio
Allopregnanolone Synthesis in Cerebellar Granule Cells: Roles in Regulation of GABAA Receptor Expression and Function during Progesterone Treatment and Withdrawal
Mol. Pharmacol., June 1, 2000; 57(6): 1262 - 1270.
[Abstract] [Full Text]

Home page
 J. Neurosci.Home page
V. C. Kotak, S. Korada, I. R. Schwartz, and D. H. Sanes
A Developmental Shift from GABAergic to Glycinergic Transmission in the Central Auditory System
J. Neurosci., June 15, 1998; 18(12): 4646 - 4655.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. D. Miranda and E. M. Barnes Jr.
Repression of gamma -Aminobutyric Acid Type A Receptor alpha 1 Polypeptide Biosynthesis Requires Chronic Agonist Exposure
J. Biol. Chem., June 27, 1997; 272(26): 16288 - 16294.
[Abstract] [Full Text] [PDF]

Home page
 J PsychopharmacolHome page
M. C. O'Donovan, P. R. Buckland, and P. McGuffin
Levels of GABAa receptor subunit mRNA in rat brain following flurazepam treatment
J Psychopharmacol, January 1, 1992; 6(3): 364 - 369.
[Abstract] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
 All ASBMB Journals   Molecular and Cellular Proteomics 
 Journal of Lipid Research   ASBMB Today 
Copyright © 1991 by the American Society for Biochemistry and Molecular Biology.