| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
J. Biol. Chem., Vol. 266, Issue 13, 8149-8155, May, 1991
JP Scott, RR Montgomery and GS Retzinger
Ristocetin in aqueous solution dimerizes with an equilibrium dissociation
constant of 5.0 x 10(-4) M, i.e. approximately 1.1 mg ml-1 (Waltho, J.P.,
and Williams, D. H. (1989) J. Am. Chem. Soc. 111, 2475- 2480). At
concentrations of about 1.0 mg ml-1 ristocetin flocculates many proteins,
lyses platelets and, in the presence of von Willebrand factor, agglutinates
both fresh and formalin-fixed platelets. Because ristocetin exists as both
monomeric and dimeric species, we sought to determine which of these forms
flocculates proteins and agglutinates platelets. We found that: 1) the
initial rate of flocculation of certain proteins, 2) the initial rate of
agglutination of formalin- fixed platelets, and 3) the binding of
ristocetin to formalin-fixed platelets are higher order solely with respect
to the concentration of ristocetin dimers. As to the operative mechanism,
it appears that bifunctional dimers cross-link proteins that possess
multiple copies of a common recognition site. Preliminary evidence
indicates that a recognition site is a beta-turn of the form X-P-G-X'.
Dimeric ristocetin flocculates proteins, binds to platelets, and mediates von Willebrand factor-dependent agglutination of platelets
Department of Pediatrics, Medical College of Wisconsin, Milwaukee 53226.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  L. J. Suva, E. Hartman, J. D. Dilley, S. Russell, N. S. Akel, R. A. Skinner, W. R. Hogue, U. Budde, K. I. Varughese, T. Kanaji, et al. Platelet Dysfunction and a High Bone Mass Phenotype in a Murine Model of Platelet-Type von Willebrand Disease Am. J. Pathol., February 1, 2008; 172(2): 430 - 439. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. J. J. Hulstein, P. J. Lenting, B. de Laat, R. H. W. M. Derksen, R. Fijnheer, and P. G. de Groot {beta}2-Glycoprotein I inhibits von Willebrand factor dependent platelet adhesion and aggregation Blood, September 1, 2007; 110(5): 1483 - 1491. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. J. J. Hulstein, P. G. de Groot, K. Silence, A. Veyradier, R. Fijnheer, and P. J. Lenting A novel nanobody that detects the gain-of-function phenotype of von Willebrand factor in ADAMTS13 deficiency and von Willebrand disease type 2B Blood, November 1, 2005; 106(9): 3035 - 3042. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Peng, M. C. Berndt, M. A. Cruz, and J. A. Lopez The {alpha}1 helix-{beta}13 strand spanning Leu214 to Val229 of platelet glycoprotein Ib{alpha} facilitates the interaction with von Willebrand factor: evidence from characterization of the epitope of monoclonal antibody AP1 Blood, December 15, 2004; 104(13): 3971 - 3978. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. A. Baglia, C. N. Shrimpton, J. Emsley, K. Kitagawa, Z. M. Ruggeri, J. A. Lopez, and P. N. Walsh Factor XI Interacts with the Leucine-rich Repeats of Glycoprotein Ib{alpha} on the Activated Platelet J. Biol. Chem., November 19, 2004; 279(47): 49323 - 49329. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Nishio, P. J. Anderson, X. L. Zheng, and J. E. Sadler Binding of platelet glycoprotein Ib{alpha} to von Willebrand factor domain A1 stimulates the cleavage of the adjacent domain A2 by ADAMTS13 PNAS, July 20, 2004; 101(29): 10578 - 10583. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-S. Chia, Y.-L. Lin, H.-T. Lien, and J.-Y. Chen Platelet Aggregation Induced by Serotype Polysaccharides from Streptococcus mutans Infect. Immun., May 1, 2004; 72(5): 2605 - 2617. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Shimizu, T. Matsushita, T. Kondo, Y. Inden, T. Kojima, H. Saito, and M. Hirai Identification of the Amino Acid Residues of the Platelet Glycoprotein Ib (GPIb) Essential for the von Willebrand Factor Binding by Clustered Charged-to-Alanine Scanning Mutagenesis J. Biol. Chem., April 16, 2004; 279(16): 16285 - 16294. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Nakayama, T. Matsushita, Z. Dong, J. E. Sadler, S. Jorieux, C. Mazurier, D. Meyer, T. Kojima, and H. Saito Identification of the Regulatory Elements of the Human von Willebrand Factor for Binding to Platelet GPIb. IMPORTANCE OF STRUCTURAL INTEGRITY OF THE REGIONS FLANKED BY THE CYS1272-CYS1458 DISULFIDE BOND J. Biol. Chem., June 7, 2002; 277(24): 22063 - 22072. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Arya, B. Anvari, G. M. Romo, M. A. Cruz, J.-F. Dong, L. V. McIntire, J. L. Moake, and J. A. Lopez Ultralarge multimers of von Willebrand factor form spontaneous high-strength bonds with the platelet glycoprotein Ib-IX complex: studies using optical tweezers Blood, May 13, 2002; 99(11): 3971 - 3977. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Kasirer-Friede, J. Ware, L. Leng, P. Marchese, Z. M. Ruggeri, and S. J. Shattil Lateral Clustering of Platelet GP Ib-IX Complexes Leads to Up-regulation of the Adhesive Function of Integrin alpha IIbbeta 3 J. Biol. Chem., March 29, 2002; 277(14): 11949 - 11956. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Cauwenberghs, K. Vanhoorelbeke, S. Vauterin, D. F. Westra, G. Romo, E. G. Huizinga, J. A. Lopez, M. C. Berndt, J. Harsfalvi, and H. Deckmyn Epitope mapping of inhibitory antibodies against platelet glycoprotein Ib{alpha} reveals interaction between the leucine-rich repeat N-terminal and C-terminal flanking domains of glycoprotein Ib{alpha} Blood, August 1, 2001; 98(3): 652 - 660. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Vasudevan, J. R. Roberts, R. A. McClintock, J. A. Dent, R. Celikel, J. Ware, K. I. Varughese, and Z. M. Ruggeri Modeling and Functional Analysis of the Interaction between von Willebrand Factor A1 Domain and Glycoprotein Ibalpha J. Biol. Chem., April 21, 2000; 275(17): 12763 - 12768. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Matsushita, D. Meyer, and J. E. Sadler Localization of von Willebrand Factor-binding Sites for Platelet Glycoprotein Ib and Botrocetin by Charged-to-Alanine Scanning Mutagenesis J. Biol. Chem., April 6, 2000; 275(15): 11044 - 11049. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Miura, C. Q. Li, Z. Cao, H. Wang, M. R. Wardell, and J. E. Sadler Interaction of von Willebrand Factor Domain A1 with Platelet Glycoprotein Ibalpha -(1-289). SLOW INTRINSIC BINDING KINETICS MEDIATE RAPID PLATELET ADHESION J. Biol. Chem., March 10, 2000; 275(11): 7539 - 7546. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Gu, X. Xi, G. D. Englund, M. C. Berndt, and X. Du Analysis of the Roles of 14-3-3 in the Platelet Glycoprotein Ib-IX-mediated Activation of Integrin {alpha}IIb{beta}3 Using a Reconstituted Mammalian Cell Expression Model J. Cell Biol., November 29, 1999; 147(5): 1085 - 1096. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Obert, A. Houllier, D. Meyer, and J.-P. Girma Conformational Changes in the A3 Domain of von Willebrand Factor Modulate the Interaction of the A1 Domain With Platelet Glycoprotein Ib Blood, March 15, 1999; 93(6): 1959 - 1968. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Miyata and Z. M. Ruggeri Distinct Structural Attributes Regulating von Willebrand Factor A1 Domain Interaction with Platelet Glycoprotein Ibalpha under Flow J. Biol. Chem., March 5, 1999; 274(10): 6586 - 6593. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. S. Retzinger, A. P. DeAnglis, and S. J. Patuto Adsorption of Fibrinogen to Droplets of Liquid Hydrophobic Phases : Functionality of the Bound Protein and Biological Implications Arterioscler. Thromb. Vasc. Biol., December 1, 1998; 18(12): 1948 - 1957. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Kenny, O. G. Jonsson, P. A. Morateck, and R. R. Montgomery Naturally Occurring Mutations in Glycoprotein Ibalpha That Result in Defective Ligand Binding and Synthesis of a Truncated Protein Blood, July 1, 1998; 92(1): 175 - 183. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Emsley, M. Cruz, R. Handin, and R. Liddington Crystal Structure of the von Willebrand Factor A1 Domain and Implications for the Binding of Platelet Glycoprotein Ib J. Biol. Chem., April 24, 1998; 273(17): 10396 - 10401. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Miyata, S. Goto, A. B. Federici, J. Ware, and Z. M. Ruggeri Conformational Changes in the A1 Domain of von Willebrand Factor Modulating the Interaction with Platelet Glycoprotein Ibalpha J. Biol. Chem., April 12, 1996; 271(15): 9046 - 9053. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Matsushita and J. E. Sadler Identification of Amino Acid Residues Essential for von Willebrand Factor Binding to Platelet Glycoprotein Ib J. Biol. Chem., June 2, 1995; 270(22): 13406 - 13414. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. E. Sanders Jr, R. L. Reddick, T. C. Nichols, K. M. Brinkhous, and M. S. Read Thrombotic Thrombocytopenia Induced in Dogs and Pigs : The Role of Plasma and Platelet vWF in Animal Models of Thrombotic Thrombocytopenic Purpura Arterioscler. Thromb. Vasc. Biol., June 1, 1995; 15(6): 793 - 800. [Abstract] [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |
