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J. Biol. Chem., Vol. 266, Issue 15, 10011-10017, 05, 1991
PL Polosa and G Attardi
Mitochondrial gene expression has been investigated in synaptic endings
from rat cerebral cortex isolated at various stages during the postnatal
development and maturation of the animal. The pattern of the mitochondrial
translation products labeled in vitro in rat brain synaptosomes revealed
some distinctive features when compared with the pattern observed in a rat
fibroblast cell line, the most remarkable being the apparent absence of
labeling of the ND5 product. This absence contrasted with the presence in
synaptosomes of an amount of ND5 mRNA comparable with that found in the rat
fibroblast cell line. The rate of mitochondrial protein synthesis per unit
amount of mtDNA in brain synaptosomes showed a characteristic reproducible
burst at 10-13 days after birth, thereafter declining sharply in the 3rd
week to reach a level that remained constant over a 2-year period. The
postnatal burst of mitochondrial protein synthesis coincided with a sharp
increase in cytochrome c oxidase activity, pointing to a phase of rapid
assembly of respiratory complexes. A comparison of the levels of
mitochondrial mRNAs with the corresponding rates of protein synthesis
during the animal development and maturation showed a lack of correlation.
These observations, together with the apparent lack of translation of the
ND5 mRNA, indicate that translational control plays a major role in the
regulation of gene expression in rat brain synaptic mitochondria.
Distinctive pattern and translational control of mitochondrial protein synthesis in rat brain synaptic endings
Division of Biology, California Institute of Technology, Pasadena 91125.
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