HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Hartmann, K. Articles by Weller, A. Search for Related Content PubMed PubMed Citation Articles by Hartmann, K. Articles by Weller, A. Social Bookmarking                      What's this?

J. Biol. Chem., Vol. 266, Issue 15, 9924-9931, May, 1991

Molecular cloning of gp 80, a glycoprotein complex secreted by kidney cells in vitro and in vivo. A link to the reproductive system and to the complement cascade

K Hartmann, J Rauch, J Urban, K Parczyk, P Diel, C Pilarsky, D Appel, W Haase, K Mann and A Weller
Abteilung Molekulare Genetik, J. W.-Goethe-Universitat Frankfurt, Federal Republic of Germany.

cDNA clones coding for the gp 80 heterodimeric glycoprotein complex secreted constitutively at the apical surface of Madin-Darby canine kidney (MDCK) cells have been isolated from MDCK cDNA libraries in lambda gt11 and lambda gt10. The cloned sequences encode a polypeptide chain of 445 amino acids. The deduced amino acid sequence of the gp 80 protein reveals 80% homology to rat SGP-2, a major secretory protein of the testes epithelium and 83% homology to SP-40,40, a human complement- associated protein. SGP-2 and SP-40,40 have been proposed to be serum and seminal forms of the same protein. The sequence homology as well as the results of Southern and Northern blot analyses and immunological studies suggest that gp 80 is the canine homolog of the rat SGP-2 and the human SP-40,40. The protein is expressed in the embryonic kidney already early during organogenesis. In the adult kidney the protein has been localized along the luminal surfaces of the proximal and distal tubule and the collecting duct cells.
CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				A. Matsuda, Y. Itoh, N. Koshikawa, T. Akizawa, I. Yana, and M. Seiki Clusterin, an Abundant Serum Factor, Is a Possible Negative Regulator of MT6-MMP/MMP-25 Produced by Neutrophils J. Biol. Chem., September 19, 2003; 278(38): 36350 - 36357. [Abstract] [Full Text] [PDF]

				J. H. Lipschutz, V. R. Lingappa, and K. E. Mostov The Exocyst Affects Protein Synthesis by Acting on the Translocation Machinery of the Endoplasmic Reticulum J. Biol. Chem., May 30, 2003; 278(23): 20954 - 20960. [Abstract] [Full Text] [PDF]

				S. Hara-Kuge, T. Ohkura, H. Ideo, O. Shimada, S. Atsumi, and K. Yamashita Involvement of VIP36 in Intracellular Transport and Secretion of Glycoproteins in Polarized Madin-Darby Canine Kidney (MDCK) Cells J. Biol. Chem., May 3, 2002; 277(18): 16332 - 16339. [Abstract] [Full Text] [PDF]

				Y. Bando, S. Ogawa, A. Yamauchi, K. Kuwabara, K. Ozawa, O. Hori, H. Yanagi, M. Tamatani, and M. Tohyama 150-kDa oxygen-regulated protein (ORP150) functions as a novel molecular chaperone in MDCK cells Am J Physiol Cell Physiol, June 1, 2000; 278(6): C1172 - C1182. [Abstract] [Full Text] [PDF]

				J. Lakins, S. A. L. Bennett, J.-H. Chen, J. M. Arnold, C. Morrissey, P. Wong, J. O'Sullivan, and M. Tenniswood Clusterin Biogenesis Is Altered during Apoptosis in the Regressing Rat Ventral Prostate J. Biol. Chem., October 23, 1998; 273(43): 27887 - 27895. [Abstract] [Full Text] [PDF]

				E. Matsubara, B. Frangione, and J. Ghiso Characterization of Apolipoprotein J-Alzheimer's Abeta Interaction J. Biol. Chem., March 31, 1995; 270(13): 7563 - 7567. [Abstract] [Full Text] [PDF]

				D Appel and C Koch-Brandt Sorting of a secretory protein (gp80) to the apical surface of Caco-2 cells J. Cell Sci., January 2, 1994; 107(2): 553 - 559. [Abstract] [PDF]