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J. Biol. Chem., Vol. 266, Issue 16, 10027-10030, 06, 1991
M Szyf, V Bozovic and G Tanigawa
The steady state level of DNA methyltransferase mRNA is markedly increased
as growth-arrested Balb/c 3T3 cells progress into the S phase of the cell
cycle. mRNA abundance is reduced to the basal level before termination of
DNA synthesis activity. Maintenance DNA methylation activity in nuclear
extracts follows a similar pattern with two exceptions. (a) A small peak of
DNA methylation activity is detected in early G1 phase. (b) The extinction
of DNA methylation activity lags behind the termination of DNA synthesis.
Nuclear runon experiments demonstrate that the gene is transcribed in
growth-arrested cells, and expression of the gene is post-transcriptionally
regulated. We suggest that this mode of regulation of the DNA
methyltransferase gene might play an important role in determining and
maintaining DNA methylation patterns.
Growth regulation of mouse DNA methyltransferase gene expression
Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada.
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