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J. Biol. Chem., Vol. 266, Issue 16, 10035-10038, Jun, 1991

Transcriptional regulation of the glucokinase gene by biotin in starved rats

J Chauhan and K Dakshinamurti
Department of Biochemistry and Molecular Biology, University of Manitoba, Winnipeg, Canada.

The purpose of this work was to investigate whether biotin, a water- soluble vitamin, regulates the glucokinase gene. Biotin was administered intraperitoneally to starved rats, and the time course of glucokinase induction was followed over a time period of 12 h. The glucokinase mRNA was increased 19.6-fold during the first 1 h after biotin administration, afterwards rapidly decayed, and was hardly detectable by 4 h. The amount of glucokinase activity as determined by conventional enzyme activity assay increased in a time-dependent fashion, reaching 4-fold by 2 h of biotin administration. The transcriptional activity of the gene as measured by a nuclear run-on assay was increased about 6.7-fold within 45 min of biotin administration. These findings indicate that biotin can regulate the glucokinase gene at the transcriptional stage in the starved rat.
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