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J. Biol. Chem., Vol. 266, Issue 19, 12157-12161, 07, 1991
N Shimizu, M Ohta, C Fujiwara, J Sagara, N Mochizuki, T Oda and H Utiyama
Human promyelocytic leukemia cell line, HL-60, undergoes macrophagic
differentiation when it is stimulated with TPA (12-O-
tetradecanoylphorbol-13-acetate). We have cloned ETR101 cDNA whose mRNA was
induced immediate early (30 min) and transiently by TPA. The mRNA is
superinduced by addition of the protein synthesis inhibitor cycloheximide.
The sequence of ETR101 cDNA (1826 base pairs) reveals that (i) it will
encode a protein of 223 amino acids with a formula molecular weight of
24,200, (ii) the amino acid sequence is highly homologous to mouse chx1
protein whose mRNA was found recently to be enhanced in activated T
lymphocytes in response to cycloheximide, (iii) the amino acid sequence is
also weakly homologous to jun family gene products, and (iv) in the mRNA
3'-flanking region, there is a unique GUUUG sequence which is complementary
to a part of B1 repetitive sequence and may be involved in mRNA
degradation. ETR101 mRNA is induced by TPA in a wide variety of leukemia
cells including myeloid, T- lymphoid, and B-lymphoid lineages. We have
found that this mRNA is also induced by okadaic acid, a protein phosphatase
inhibitor, and that TPA or cycloheximide act synergistically with okadaic
acid. In addition, the induction is inhibited by protein kinase C
inhibitors. Therefore, ETR101 mRNA level is controlled, either directly or
indirectly, by protein phosphorylation.
Expression of a novel immediate early gene during 12-O- tetradecanoylphorbol-13-acetate-induced macrophagic differentiation of HL-60 cells
Life Science Group, Faculty of Integrated Arts and Sciences, Hiroshima University, Japan.
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