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J. Biol. Chem., Vol. 266, Issue 22, 14139-14142, Aug, 1991
PJ Roach
Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis 46202-5122.
Multisite phosphorylation is a prevalent form of protein modification whose full implications are just beginning to be understood. Multiple protein modifications expand the repertoire of structural changes that can be elicited in proteins and permit more intricate regulatory circuits to operate.
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|
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|
|
|
|
|
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|
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|
|
|
|
|
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