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J. Biol. Chem., Vol. 266, Issue 22, 14183-14187, 08, 1991
R Hromas, SJ Collins, D Hickstein, W Raskind, LL Deaven, P O'Hara, FS Hagen and K Kaushansky
Zinc finger genes encode metal-binding proteins that can act as
transcriptional regulators of other genes. In an effort to identify
activators of the genetic cascade in hemopoietic differentiation, we used
degenerate synthetic oligonucleotides to the conserved zinc finger
histidine-cysteine link to probe a human myeloid lambda gt11 cDNA library.
One of the cDNA clones obtained hybridized preferentially to mRNA from
myeloid cells. This cDNA was used to isolate clones encompassing the coding
region for this gene. Sequence analysis found 13 zinc finger regions and a
glycine-proline-rich region between the fourth and fifth zinc finger
domain. The gene was localized to chromosome 19q13.2-4, a chromosome that
has a large cluster of zinc finger genes. The gene was preferentially
expressed in myeloid leukemia cell lines with the highest mRNA levels noted
in HL-60 cells induced to differentiate with retinoic acid. Thus, this new
zinc finger gene (designated MZF-1) may be one regulator of transcriptional
events during hemopoietic development.
A retinoic acid-responsive human zinc finger gene, MZF-1, preferentially expressed in myeloid cells
Division of Hematology-Oncology, Indiana University Medical Center, Indianapolis 46202-5121.
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