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J. Biol. Chem., Vol. 266, Issue 23, 15035-15041, Aug, 1991
BG Szaro, HC Pant, J Way and J Battey
The primary structure of the major 60-kDa squid low molecular mass
neurofilament protein (NF60) and a related 70-kDa neurofilament protein
have been determined from cDNA clones isolated from a squid brain cDNA
library. Structural analysis suggests that the squid NF60 and NF70
neurofilament genes and proteins are remarkably distinct from vertebrate
neuronal intermediate filaments characterized previously. Both proteins are
encoded on mRNAs generated by alternative RNA processing of the primary
transcript of a single gene. Among the known intermediate filament
proteins, NF60 and NF70 neurofilament proteins show highest similarity to
an epithelial intermediate filament protein from Helix pomatia, a gastropod
mollusk, and are less similar to vertebrate neurofilaments. The length of
the alpha-helical rod domain in the NF60 and NF70 proteins was reminiscent
of the vertebrate nuclear lamins, 6 heptads longer than is found in all
known vertebrate cytoplasmic intermediate filaments, in particular the
vertebrate neurofilaments. These distinct structural properties suggest
that the vertebrate and invertebrate low molecular weight neurofilaments
evolved independently from primordial intermediate filament proteins.
Squid low molecular weight neurofilament proteins are a novel class of neurofilament protein. A nuclear lamin-like core and multiple distinct proteins formed by alternative RNA processing
Laboratory of Neurochemistry, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland 20892.
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