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J. Biol. Chem., Vol. 266, Issue 25, 16261-16264, 09, 1991
TG Tessner, CO Rock, GB Kalmar, RB Cornell and S Jackowski
Growth factor regulation of phosphatidylcholine (PtdCho) metabolism during
the G1 stage of the cell cycle was investigated in the colony- stimulating
factor 1 (CSF-1)-dependent murine macrophage cell-line BAC1.2F5. The
transient removal of CSF-1 arrested the cells in G1. Incorporation of
[3H]choline into PtdCho was stimulated significantly 1 h after growth
factor addition to quiescent cells. Metabolic labeling experiments pointed
to CTP:phosphocholine cytidylyltransferase (CT) as the rate-controlling
enzyme for PtdCho biosynthesis in BAC1.2F5 cells. The amount of CT mRNA
increased 4-fold within 15 min of CSF-1 addition and remained elevated for
2 h. The rise in CT mRNA levels was accompanied by a 50% increase in total
CT specific activity in cell extracts within 4 h after the addition of
CSF-1. CSF-1-dependent elevation of CT mRNA content was neither attenuated
nor superinduced by the inhibition of protein synthesis with cycloheximide.
The rate of CT mRNA turnover decreased in the presence of CSF-1 indicating
that message stabilization was a key factor in determining the levels of CT
mRNA. These data point to increased CT mRNA abundance as a component in
growth factor-stimulated PtdCho synthesis.
Colony-stimulating factor 1 regulates CTP: phosphocholine cytidylyltransferase mRNA levels
Department of Biochemistry, St. Jude Children's Research Hospital, Memphis, Tennessee 38105.
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