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J. Biol. Chem., Vol. 266, Issue 3, 1363-1366, 01, 1991
PA Loessberg, H Zhao and S Muallem
Oscillation in [Ca2+]i induced by agonists has been described in many cell
types and is thought to reflect Ca2+ release from and uptake into internal
stores. We measured [Ca2+]i and Mn2+ entry in single cells of the
pancreatic acinar cell line AR42J loaded with Fura 2 to examine the
behavior of Ca2+ influx across the plasma membrane (Ca2+ entry) during
agonist-evoked [Ca2+]i oscillation. Addition of extracellular Ca2+
(Ca2+out) to agonist-stimulated cells bathed in Ca2(+)-free medium resulted
in a marked [Ca2+]i increase blocked by La3+. The use of Mn2+ as a congener
of Ca2+ to follow unidirectional Ca2+ movement reveals an oscillatory
activation of Ca2+ entry by Ca2(+)-mobilizing agonists. The frequency at
which Ca2+ entry oscillated matched the frequency of Ca2+ release from
intracellular stores. Ca2+ entry is activated after completion of Ca2+
release and is inactivated within the time span of each [Ca2+]i spike.
These studies reveal a new aspect of [Ca2+]i oscillation in
agonist-stimulated cells, that is the oscillatory activation of [Ca2+]i
entry during [Ca2+]i oscillation.
Synchronized oscillation of Ca2+ entry and Ca2+ release in agonist- stimulated AR42J cells
Department of Physiology, University of Texas Southwestern Medical Center, Dallas 75235.
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