| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
J. Biol. Chem., Vol. 266, Issue 3, 1491-1496, Jan, 1991
P Dunten and DE Koshland Jr
Down-regulation or adaptation of receptors is an essential part of the
chemotaxis mechanism to sense gradients. Using localized mutagenesis it is
shown that the covalent modification of the receptors makes a slight change
in the binding constant (factor of 2) which is far too small to explain the
adaptation. The modification does, however, alter the signaling
dramatically, an increasing tumbling signal being correlated with increased
covalent modification. Responses in the two extreme cases, namely,
completely unmodified and completely modified receptor, occur at attractant
concentrations separated by 2 orders of magnitude. Amidation of the
regulatory glutamate residues causes essentially the same signaling change
as methylation. Thus, adaptation in chemotaxis is due to modulation of the
receptor's signaling properties, not its affinity for the chemoeffector.
Tuning the responsiveness of a sensory receptor via covalent modification
Department of Molecular and Cell Biology, University of California, Berkeley 94720.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  T. Y. Besschetnova, D. J. Montefusco, A. E. Asinas, A. L. Shrout, F. M. Antommattei, and R. M. Weis Receptor density balances signal stimulation and attenuation in membrane-assembled complexes of bacterial chemotaxis signaling proteins PNAS, August 26, 2008; 105(34): 12289 - 12294. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. E. Asinas and R. M. Weis Competitive and Cooperative Interactions in Receptor Signaling Complexes J. Biol. Chem., October 13, 2006; 281(41): 30512 - 30523. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Irieda, M. Homma, M. Homma, and I. Kawagishi Control of Chemotactic Signal Gain via Modulation of a Pre-formed Receptor Array J. Biol. Chem., August 18, 2006; 281(33): 23880 - 23886. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. L. Skoge, R. G. Endres, and N. S. Wingreen Receptor-Receptor Coupling in Bacterial Chemotaxis: Evidence for Strongly Coupled Clusters Biophys. J., June 15, 2006; 90(12): 4317 - 4326. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. E. Keymer, R. G. Endres, M. Skoge, Y. Meir, and N. S. Wingreen Chemosensing in Escherichia coli: Two regimes of two-state receptors PNAS, February 7, 2006; 103(6): 1786 - 1791. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Shiomi, S. Banno, M. Homma, and I. Kawagishi Stabilization of Polar Localization of a Chemoreceptor via Its Covalent Modifications and Its Communication with a Different Chemoreceptor J. Bacteriol., November 15, 2005; 187(22): 7647 - 7654. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. A. Mello and Y. Tu Perfect and Near-Perfect Adaptation in a Model of Bacterial Chemotaxis Biophys. J., May 1, 2003; 84(5): 2943 - 2956. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. N. Levit and J. B. Stock Receptor Methylation Controls the Magnitude of Stimulus-Response Coupling in Bacterial Chemotaxis J. Biol. Chem., September 20, 2002; 277(39): 36760 - 36765. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.-H. Kim, W. Wang, and K. K. Kim Dynamic and clustering model of bacterial chemotaxis receptors: Structural basis for signaling and high sensitivity PNAS, September 3, 2002; 99(18): 11611 - 11615. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Bray Bacterial chemotaxis and the question of gain PNAS, January 8, 2002; 99(1): 7 - 9. [Full Text] [PDF]
|
|
|
|
|
|
O. J. Murphy III, X. Yi, R. M. Weis, and L. K. Thompson Hydrogen Exchange Reveals a Stable and Expandable Core within the Aspartate Receptor Cytoplasmic Domain J. Biol. Chem., November 9, 2001; 276(46): 43262 - 43269. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Jasuja, Yu-Lin, D. R. Trentham, and S. Khan Response tuning in bacterial chemotaxis PNAS, September 28, 1999; 96(20): 11346 - 11351. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Feng, A. A. Lilly, and G. L. Hazelbauer Enhanced Function Conferred on Low-Abundance Chemoreceptor Trg by a Methyltransferase-Docking Site J. Bacteriol., May 15, 1999; 181(10): 3164 - 3171. [Abstract] [Full Text]
|
|
|
|
|
|
H. Okumura, S.-i. Nishiyama, A. Sasaki, M. Homma, and I. Kawagishi Chemotactic Adaptation Is Altered by Changes in the Carboxy-Terminal Sequence Conserved among the Major Methyl-Accepting Chemoreceptors J. Bacteriol., April 1, 1998; 180(7): 1862 - 1868. [Abstract] [Full Text]
|
|
|
|
|
|
T. Iwama, M. Homma, and I. Kawagishi Uncoupling of Ligand-binding Affinity of the Bacterial Serine Chemoreceptor from Methylation- and Temperature-modulated Signaling States J. Biol. Chem., May 23, 1997; 272(21): 13810 - 13815. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Nara, I. Kawagishi, S.-i. Nishiyama, M. Homma, and Y. Imae Modulation of the Thermosensing Profile of the Escherichia coli Aspartate Receptor Tar by Covalent Modification of Its Methyl-accepting Sites J. Biol. Chem., July 26, 1996; 271(30): 17932 - 17936. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Zimmer, J. Tiu, M. A. Collins, and G. W. Ordal Selective Methylation Changes on the Bacillus subtilis Chemotaxis Receptor McpB Promote Adaptation J. Biol. Chem., August 4, 2000; 275(32): 24264 - 24272. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M. Bjorkman, P. Dunten, M. O. J. Sandgren, V. N. Dwarakanath, and S. L. Mowbray Mutations That Affect Ligand Binding to the Escherichia coli Aspartate Receptor. IMPLICATIONS FOR TRANSMEMBRANE SIGNALING J. Biol. Chem., January 19, 2001; 276(4): 2808 - 2815. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Sourjik and H. C. Berg Receptor sensitivity in bacterial chemotaxis PNAS, January 8, 2002; 99(1): 123 - 127. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |
