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J. Biol. Chem., Vol. 266, Issue 32, 21331-21334, Nov, 1991

Expression of the human beta-amyloid protein of Alzheimer's disease specifically in the brains of transgenic mice

FA Sandhu, M Salim and SB Zain
Department of Biochemistry, University of Rochester School of Medicine, New York 14642.

The human beta-amyloid protein is deposited in senile plaques and in the cerebro-vasculature of people with Alzheimer's disease and Down's syndrome. The precise role of beta-amyloid in Alzheimer's disease pathology is presently unknown. To study the properties of beta-amyloid in vivo, we generated transgenic mice that harbor the gene for the carboxyl-terminal 100 amino acids of the human amyloid precursor protein, beginning with the beta-amyloid region, under control of the JC viral early region promoter. The mRNA is expressed exclusively in brain tissue. Further, we demonstrate increased levels of beta-amyloid immunoreactivity on fixed brain tissue. These animals will be useful as a model to study beta-amyloid deposition and its consequences.
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