| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
J. Biol. Chem., Vol. 266, Issue 32, 21381-21385, 11, 1991
E Dumermuth, EE Sterchi, WP Jiang, RL Wolz, JS Bond, AV Flannery and RJ Beynon
Molecular cloning of a human intestinal brush border metalloendopeptidase
(N-benzoyl-L-tyrosyl-p-aminobenzoic acid hydrolase, PPH) and a mouse kidney
brush border metalloendopeptidase (meprin A) has revealed 82% identity in
the NH2-terminal amino acid sequences (198 residues) of the mature enzymes.
Furthermore, searching of protein sequence data bases with the inferred
peptide sequences as probes revealed strong similarities to astacin, a
crayfish digestive protease, and an NH2-terminal domain of a human bone
morphogenetic protein (BMP-1). Meprin A and PPH both have approximately 30%
identity with astacin and BMP-1. Multiple alignment analysis indicated that
37 residues, including 3 cysteine residues, are strictly conserved for the
four proteins in a sequence frame equivalent to the complete 200-amino acid
astacin sequence. The four proteins contain a zinc-binding motif (HEXXH),
found at the active site of most metalloendopeptidases, within an extended
sequence of HEXXHXXGFXHE which is unique to this subgroup of
metalloendopeptidases. In addition, the four proteins have 54% identity in
a 24-amino acid sequence that includes the putative active site. A fifth
protein, Xenopus laevis developmentally regulated protein UVS.2, also
shares sequence identity with the metalloendopeptidases. These data provide
strong evidence for an evolutionary relationship of these proteins. It is
suggested that this new family of metalloendopeptidases be called the
"astacin family."
The astacin family of metalloendopeptidases
Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Berne, Switzerland.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  T. Kijimoto, M. Watanabe, K. Fujimura, M. Nakazawa, Y. Murakami, S. Kuratani, Y. Kohara, T. Gojobori, and N. Okada cimp1, A Novel Astacin Family Metalloproteinase Gene from East African Cichlids, Is Differentially Expressed Between Species During Growth Mol. Biol. Evol., August 1, 2005; 22(8): 1649 - 1660. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Garrigue-Antar, V. Francois, and K. E. Kadler Deletion of Epidermal Growth Factor-like Domains Converts Mammalian Tolloid into a Chordinase and Effective Procollagen C-proteinase J. Biol. Chem., November 26, 2004; 279(48): 49835 - 49841. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Quesada, L. M. Sanchez, J. Alvarez, and C. Lopez-Otin Identification and Characterization of Human and Mouse Ovastacin: A NOVEL METALLOPROTEINASE SIMILAR TO HATCHING ENZYMES FROM ARTHROPODS, BIRDS, AMPHIBIANS, AND FISH J. Biol. Chem., June 18, 2004; 279(25): 26627 - 26634. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Garrigue-Antar, N. Hartigan, and K. E. Kadler Post-translational Modification of Bone Morphogenetic Protein-1 Is Required for Secretion and Stability of the Protein J. Biol. Chem., November 1, 2002; 277(45): 43327 - 43334. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Rosmann, D. Hahn, D. Lottaz, M.-N. Kruse, W. Stocker, and E. E. Sterchi Activation of Human Meprin-alpha in a Cell Culture Model of Colorectal Cancer Is Triggered by the Plasminogen-activating System J. Biol. Chem., October 18, 2002; 277(43): 40650 - 40658. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Lottaz, C. A. Maurer, D. Hahn, M. W. Buchler, and E. E. Sterchi Nonpolarized Secretion of Human Meprin {{alpha}} in Colorectal Cancer Generates an Increased Proteolytic Potential in the Stroma Cancer Res., March 1, 1999; 59(5): 1127 - 1133. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Litovchick, A. Chestukhin, and S. Shaltiel The Carboxyl-terminal Tail of Kinase Splitting Membranal Proteinase/Meprin beta Is Involved in Its Intracellular Trafficking J. Biol. Chem., October 30, 1998; 273(44): 29043 - 29051. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Gao and D. L. Garbers Species Diversity in the Structure of Zonadhesin, a Sperm-specific Membrane Protein Containing Multiple Cell Adhesion Molecule-like Domains J. Biol. Chem., February 6, 1998; 273(6): 3415 - 3421. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. D. Johnson and J. S. Bond Activation Mechanism of Meprins, Members of the Astacin Metalloendopeptidase Family J. Biol. Chem., October 31, 1997; 272(44): 28126 - 28132. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Q.-R Liu, S. Hattar, S. Endo, K. MacPhee, H. Zhang, L. J. Cleary, J. H. Byrne, and A. Eskin A Developmental Gene (Tolloid/BMP-1) Is Regulated in Aplysia Neurons by Treatments that Induce Long-Term Sensitization J. Neurosci., January 15, 1997; 17(2): 755 - 764. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N Suzuki, P. Labosky, Y Furuta, L Hargett, R Dunn, A. Fogo, K Takahara, D. Peters, D. Greenspan, and B. Hogan Failure of ventral body wall closure in mouse embryos lacking a procollagen C-proteinase encoded by Bmp1, a mammalian gene related to Drosophila tolloid Development, January 11, 1996; 122(11): 3587 - 3595. [Abstract] [PDF]
|
|
|
|
|
|
P. Keller, L. Zecca, R. Boukamel, E. Zwicker, S. Gloor, and G. Semenza Furin, PC1/3, and/or PC6A Process Rabbit, but Not Human, Pro-lactase-phlorizin Hydrolase to the 180-kDa Intermediate J. Biol. Chem., October 27, 1995; 270(43): 25722 - 25728. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. C. M. Zondag, G. M. Koningstein, Y.-P. Jiang, J. Sap, W. H. Moolenaar, and M. F. B. G. Gebbink Homophilic Interactions Mediated by Receptor Tyrosine Phosphatases ΅ and [IMAGE] J. Biol. Chem., June 16, 1995; 270(24): 14247 - 14250. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Kojro and F. Fahrenholz Ligand-induced Cleavage of the V(2) Vasopressin Receptor by a Plasma Membrane Metalloproteinase J. Biol. Chem., March 24, 1995; 270(12): 6476 - 6481. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L Yan, G. Pollock, H Nagase, and M. Sarras A 25.7 x 10(3) M(r) hydra metalloproteinase (HMP1), a member of the astacin family, localizes to the extracellular matrix of Hydra vulgaris in a head-specific manner and has a developmental function Development, January 6, 1995; 121(6): 1591 - 1602. [Abstract] [PDF]
|
|
|
|
|
|
B Spencer-Dene, P Thorogood, S Nair, A. Kenny, M Harris, and B Henderson Distribution of, and a putative role for, the cell-surface neutral metallo-endopeptidases during mammalian craniofacial development Development, January 11, 1994; 120(11): 3213 - 3226. [Abstract] [PDF]
|
|
|
|
|
|
S. Hwang, J. Partin, and W. Lennarz Characterization of a homolog of human bone morphogenetic protein 1 in the embryo of the sea urchin, Strongylocentrotus purpuratus Development, January 3, 1994; 120(3): 559 - 568. [Abstract] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |
