![]()
|
|
||||||||
J. Biol. Chem., Vol. 266, Issue 32, 21523-21529, Nov, 1991
TN Parks, AL Mueller, LD Artman, BC Albensi, EF Nemeth, H Jackson, VJ Jasys, NA Saccomano and RA Volkmann
The venom of the North American funnel-web spider Agelenopsis aperta
contains a variety of arylamine toxins (the alpha-agatoxins) that paralyze
insects by blocking glutamatergic neuromuscular transmission. We have
tested six synthetic alpha-agatoxins for their ability to antagonize
glutamate receptor function in mammalian brain. These compounds produce, at
submicromolar concentrations, noncompetitive inhibition of
N-methyl-D-aspartate (NMDA) receptor-mediated elevations in the
concentration of cytosolic free calcium in cultured rat cerebellar granule
neurons. In contrast, the alpha-agatoxins are relatively weak antagonists
of elevations in the cytosolic free calcium concentration induced by
non-NMDA receptor agonists. The alpha- agatoxins also produce reversible
suppression of the NMDA receptor- mediated excitatory postsynaptic
potential in rat hippocampal slices at concentrations that have little
effect on the non-NMDA receptor- mediated population spike. We conclude
that the alpha-agatoxins are selective and reversible noncompetitive
antagonists at NMDA receptors in mammalian brain.
Arylamine toxins from funnel-web spider (Agelenopsis aperta) venom antagonize N-methyl-D-aspartate receptor function in mammalian brain
Natural Product Sciences Inc., Salt Lake City, Utah 84108.
![]()
CiteULike
Complore
Connotea
Del.icio.us
Digg
Reddit
Technorati What's this?
This article has been cited by other articles:
![]() |
B. C. Albensi, C. Igoechi, D. Janigro, and E. Ilkanich Why do many NMDA antagonists fail, while others are safe and effective at blocking excitotoxicity associated with dementia and acute injury? American Journal of Alzheimer's Disease and Other Dementias, September 1, 2004; 19(5): 269 - 274. [Abstract] [PDF] |
||||
![]() |
J. Chao, N. Seiler, J. Renault, K. Kashiwagi, T. Masuko, K. Igarashi, and K. Williams N1-Dansyl-Spermine and N1-(n-Octanesulfonyl)-Spermine, Novel Glutamate Receptor Antagonists: Block and Permeation of N-Methyl-D-Aspartate Receptors Mol. Pharmacol., May 1, 1997; 51(5): 861 - 871. [Abstract] [Full Text] |
||||
![]() |
M. C. Sanguinetti, J. H. Johnson, L. G. Hammerland, P. R. Kelbaugh, R. A. Volkmann, N. A. Saccomano, and A. L. Mueller Heteropodatoxins: Peptides Isolated from Spider Venom that Block Kv4.2 Potassium Channels Mol. Pharmacol., March 1, 1997; 51(3): 491 - 498. [Abstract] [Full Text] [PDF] |
||||
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |