| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
J. Biol. Chem., Vol. 266, Issue 32, 21530-21536, Nov, 1991
C Betzel, G Lange, GP Pal, KS Wilson, A Maelicke and W Saenger
The crystal structure of the "long" alpha-neurotoxin alpha-cobratoxin was
refined to an R-factor of 19.5% using 3271 x-ray data to 2.4-A resolution.
The polypeptide chain forms three loops, I, II, III, knotted together by
four disulfide bridges, with the most prominent, loop II, containing
another disulfide close to its lower tip. Loop I is stabilized by one
beta-turn and two beta-sheet hydrogen bonds; loop II by eight beta-sheet
hydrogen bonds, with the tip folded into two distorted right-handed helical
turns stabilized by two alpha-helical and two beta-turn hydrogen bonds; and
loop III by hydrophobic interactions and one beta-turn. Loop II and one
strand of loop III form an antiparallel triple-pleated beta-sheet, and
tight anchoring of the Asn63 side chain fixes the tail segment. In the
crystal lattice, the alpha-cobratoxin molecules dimerize by beta-sheet
formation between strands 53 and 57 of symmetry-related molecules. Because
such interactions are found also in a cardiotoxin and alpha-bungarotoxin,
this could be of importance for interaction with acetylcholine receptor.
The refined crystal structure of alpha-cobratoxin from Naja naja siamensis at 2.4-A resolution
European Molecular Biology Laboratory, Deutsches Elektronen Synchrotron, Hamburg, Federal Republic of Germany.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  J. M. O'Leary, J. M. Hamilton, C. M. Deane, N. V. Valeyev, L. J. Sandell, and A. K. Downing Solution Structure and Dynamics of a Prototypical Chordin-like Cysteine-rich Repeat (von Willebrand Factor Type C Module) from Collagen IIA J. Biol. Chem., December 17, 2004; 279(51): 53857 - 53866. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Lou, Q. Liu, X. Tu, J. Wang, M. Teng, L. Niu, D. J. Schuller, Q. Huang, and Q. Hao The Atomic Resolution Crystal Structure of Atratoxin Determined by Single Wavelength Anomalous Diffraction Phasing J. Biol. Chem., September 10, 2004; 279(37): 39094 - 39104. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. S. Young, L. G. Herbette, and V. Skita {alpha}-Bungarotoxin Binding to Acetylcholine Receptor Membranes Studied by Low Angle X-Ray Diffraction Biophys. J., August 1, 2003; 85(2): 943 - 953. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Zeng and E. Hawrot NMR-based Binding Screen and Structural Analysis of the Complex Formed between alpha -Cobratoxin and an 18-Mer Cognate Peptide Derived from the alpha 1 Subunit of the Nicotinic Acetylcholine Receptor from Torpedo californica J. Biol. Chem., September 27, 2002; 277(40): 37439 - 37445. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Nirthanan, E. Charpantier, P. Gopalakrishnakone, M. C. E. Gwee, H.-E. Khoo, L.-S. Cheah, D. Bertrand, and R. M. Kini Candoxin, a Novel Toxin from Bungarus candidus, Is a Reversible Antagonist of Muscle (alpha beta gamma delta ) but a Poorly Reversible Antagonist of Neuronal alpha 7 Nicotinic Acetylcholine Receptors J. Biol. Chem., May 10, 2002; 277(20): 17811 - 17820. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Moise, A. Piserchio, V. J. Basus, and E. Hawrot NMR Structural Analysis of alpha -Bungarotoxin and Its Complex with the Principal alpha -Neurotoxin-binding Sequence on the alpha 7 Subunit of a Neuronal Nicotinic Acetylcholine Receptor J. Biol. Chem., March 29, 2002; 277(14): 12406 - 12417. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Fruchart-Gaillard, B. Gilquin, S. Antil-Delbeke, N. Le Novere, T. Tamiya, P.-J. Corringer, J.-P. Changeux, A. Menez, and D. Servent Experimentally based model of a complex between a snake toxin and the alpha 7 nicotinic receptor PNAS, February 20, 2002; (2002) 42699899. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. H. Chou, C. I. Bargmann, and P. Sengupta The Caenorhabditis elegans odr-2 Gene Encodes a Novel Ly-6-Related Protein Required for Olfaction Genetics, January 1, 2001; 157(1): 211 - 224. [Abstract] [Full Text]
|
|
|
|
|
|
A. Ricciardi, M.-H. le Du, M. Khayati, F. Dajas, J.-C. Boulain, A. Menez, and F. Ducancel Do Structural Deviations between Toxins Adopting the Same Fold Reflect Functional Differences? J. Biol. Chem., June 9, 2000; 275(24): 18302 - 18310. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Antil, D. Servent, and A. Menez Variability among the Sites by Which Curaremimetic Toxins Bind to Torpedo Acetylcholine Receptor, as Revealed by Identification of the Functional Residues of alpha -Cobratoxin J. Biol. Chem., December 3, 1999; 274(49): 34851 - 34858. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Scherf, M. Balass, S. Fuchs, E. Katchalski-Katzir, and J. Anglister Three-dimensional solution structure of the complex of alpha -bungarotoxin with a library-derived peptide PNAS, June 10, 1997; 94(12): 6059 - 6064. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.-S. Peng, T. K. S. Kumar, G. Jayaraman, C.-C. Chang, and C. Yu Solution Structure of Toxin b, a Long Neurotoxin from the Venom of the King Cobra (Ophiophagus hannah) J. Biol. Chem., March 21, 1997; 272(12): 7817 - 7823. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. N. Utkin, V. V. Kukhtina, E. V. Kryukova, F. Chiodini, D. Bertrand, C. Methfessel, and V. I. Tsetlin "Weak Toxin" from Naja kaouthia Is a Nontoxic Antagonist of alpha 7 and Muscle-type Nicotinic Acetylcholine Receptors J. Biol. Chem., May 4, 2001; 276(19): 15810 - 15815. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Antil-Delbeke, C. Gaillard, T. Tamiya, P.-J. Corringer, J.-P. Changeux, D. Servent, and A. Menez Molecular Determinants by Which a Long Chain Toxin from Snake Venom Interacts with the Neuronal alpha 7-Nicotinic Acetylcholine Receptor J. Biol. Chem., September 15, 2000; 275(38): 29594 - 29601. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Fruchart-Gaillard, B. Gilquin, S. Antil-Delbeke, N. Le Novere, T. Tamiya, P.-J. Corringer, J.-P. Changeux, A. Menez, and D. Servent Experimentally based model of a complex between a snake toxin and the alpha 7 nicotinic receptor PNAS, March 5, 2002; 99(5): 3216 - 3221. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |
