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J. Biol. Chem., Vol. 266, Issue 35, 23670-23675, Dec, 1991

Complete structure of the glycan of lipopeptidophosphoglycan from Trypanosoma cruzi Epimastigotes

RM de Lederkremer, C Lima, MI Ramirez, MA Ferguson, SW Homans and J Thomas-Oates
Departamento de Quimica Organica, Facultad de Ciencas Exactas y Naturales, Universidad de Buenos Aires, Argentina.

The lipopeptidophosphoglycan is the major cell surface glycoconjugate of the epimastigote forms of the parasitic protozoan Trypanosoma cruzi. A detailed partial structure for this molecule has been reported (Previato, J. O., Gorin, P. A. J., Mazurek, M., Xavier, M. T., Fournet, B., Wieruszesk, J. M., and Mendonca-Previato, L. (1990) J. Biol. Chem. 265, 2518-2526). In this study, we complete the primary structure assignments and describe the microheterogeneity found in the lipopeptidophosphoglycan glycan, using a combination of 1H and 31P NMR, fast atom bombardment mass spectrometry, methylation linkage analysis, and exoglycosidase sequencing. The lipopeptidophosphoglycan is a glycosylated inositol-phosphoceramide with striking homology to glycosylphosphatidylinositol membrane anchors found attached to a wide variety of plasma membrane proteins throughout the eukaryotes.
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