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J. Biol. Chem., Vol. 266, Issue 35, 23790-23795, 12, 1991
AM Leone, RM Palmer, RG Knowles, PL Francis, DS Ashton and S Moncada
Nitric oxide (NO) is synthesized by a number of cells from a guanidino
nitrogen atom of L-arginine by the action of either constitutive or
inducible NO synthases, both of which form citrulline as a co-product. We
have determined the source of the oxygen in both NO and in citrulline
formed by the constitutive NO synthase from the vascular endothelium and
brain and by the inducible NO synthase from the murine macrophage cell line
J774. All these enzymes incorporate molecular oxygen both into NO and into
citrulline. Furthermore, activated J774 cells form NO from
omega-hydroxyl-L-arginine, confirming the proposal that this compound is an
intermediate in the biosynthesis of NO.
Constitutive and inducible nitric oxide synthases incorporate molecular oxygen into both nitric oxide and citrulline
Wellcome Research Laboratories, Beckenham, Kent, United Kingdom.
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