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J. Biol. Chem., Vol. 266, Issue 9, 5375-5383, 03, 1991
T Toyofuku and R Zak
We report on the isolation and characterization of cDNA and genomic
sequences encoding a chicken cardiac phospholamban. Three mRNAs, 0.6, 1.1,
and 3.3 kilobase pairs in size, were detected in cardiac and slow- tonic
muscle RNAs on Northern blots. We determined that these mRNAs differ in the
length of their 3'-untranslated regions, perhaps because they utilize
alternative polyadenylation signals. We studied the developmental and
tissue-specific expression of phospholamban mRNA using nuclease mapping
analysis. There appeared to be considerable homology between coding and
3'-untranslated regions of phospholamban mRNAs from cardiac and slow-tonic
muscles during development, strongly suggesting that these mRNAs are
encoded by the same gene. The phospholamban gene, which is present as a
single copy in the chicken genome, is about 10 kilobase pairs long, with
approximately 6.5 kilobase pairs representing the intron sequences. Primer
extension and nuclease mapping analyses of the 5' end of the phospholamban
mRNA showed that the three transcripts are initiated from the same
initiation site. Analysis of the putative promoter region revealed "TATA
box" and "CAAT box" sequences, putative muscle-specific elements, and a
cyclic AMP-responsive element.
Characterization of cDNA and genomic sequences encoding a chicken phospholamban
Department of Medicine, University of Chicago, Illinois 60637.
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