| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
J. Biol. Chem., Vol. 267, Issue 17, 11908-11916, Jun, 1992
S Bourgoin and S Grinstein
To determine the role of protein tyrosine phosphorylation in the activation
of phospholipase D (PLD), electropermeabilized HL-60 cells labeled in
[3H]alkyl-phosphatidylcholine were treated with vanadate derivatives.
Micromolar concentrations of vanadyl hydroperoxide (V(4+)- OOH) induced
accumulation of tyrosine-phosphorylated proteins. Concomitantly, V(4+)-OOH
or a combination of vanadate and NADPH elicited a concentration- and
time-dependent accumulation of phosphatidic acid (PtdOH). In the presence
of ethanol a sustained formation of phosphatidylethanol was observed,
indicating that a type D phospholipase was activated. A good correlation
was found to exist between the accumulation of tyrosine-phosphorylated
proteins and activation of PLD. The V(4+)-OOH concentration dependence of
the two responses was nearly identical, and the time course of activation
was similar, with tyrosine phosphorylation preceding PLD activation by
approximately 1 min. The ability of V(4+)-OOH to induce both responses was
found to be strictly dependent on the presence of ATP and/or Mg2+,
suggesting that PLD activation involves phosphotransferase reactions.
Accordingly, ST638, a tyrosine kinase inhibitor, reduced concomitantly
tyrosine phosphorylation and PLD activation elicited by V(4+)-OOH. The
mechanism of action of V(4+)-OOH was investigated. The diacylglycerol
kinase inhibitors, dioctanoylethylene glycol and R59022 potentiated PLD
stimulation by exogenous diacylglycerol but not by V(4+)-OOH. Moreover,
stimulation by V(4+)-OOH and by phorbol esters was synergystic. Therefore,
diacylglycerol-induced activation of protein kinase C is unlikely to
mediate the effects of V(4+)-OOH. The response of PLD to V(4+)-OOH was
larger than that to guanosine 5'-(gamma- thio)triphosphate. Moreover, the
effects of GTP gamma S and V(4+)-OOH were additive. Hence, activation of G
proteins cannot account for the stimulation of PLD by V(4+)-OOH. V(4+)-OOH
also triggers a burst of O2 consumption by the NADPH oxidase. Inhibition of
PtdOH accumulation by addition of ethanol or by ST638 abolished this
respiratory burst. Together, the results establish a strong correlation
between tyrosine phosphorylation, PLD activation, and stimulation of the
NADPH oxidase in HL-60 cells, suggesting a causal relationship.
Peroxides of vanadate induce activation of phospholipase D in HL-60 cells. Role of tyrosine phosphorylation
Division of Cell Biology, Hospital for Sick Children, Toronto, Canada.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  J. Ziembicki, R. Tandon, J. R. Schelling, J. R. Sedor, R. T. Miller, and C. Huang Mechanical force-activated phospholipase D is mediated by G{alpha}12/13-Rho and calmodulin-dependent kinase in renal epithelial cells Am J Physiol Renal Physiol, October 1, 2005; 289(4): F826 - F834. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. R. Santhamma, R. Sadhukhan, M. Kinter, S. Chattopadhyay, B. McCue, and I. Sen Role of Tyrosine Phosphorylation in the Regulation of Cleavage Secretion of Angiotensin-converting Enzyme J. Biol. Chem., September 17, 2004; 279(38): 40227 - 40236. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. S. Choi, T. Hiragun, J. H. Lee, Y. M. Kim, H.-P. Kim, A. Chahdi, E. Her, J. W. Han, and M. A. Beaven Activation of RBL-2H3 Mast Cells Is Dependent on Tyrosine Phosphorylation of Phospholipase D2 by Fyn and Fgr Mol. Cell. Biol., August 15, 2004; 24(16): 6980 - 6992. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Chen, M. O. Daines, and G. K. K. Hershey Methylation of STAT6 Modulates STAT6 Phosphorylation, Nuclear Translocation, and DNA-Binding Activity J. Immunol., June 1, 2004; 172(11): 6744 - 6750. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Zamorano, M. D. Rivas, A. Garcia-Trinidad, C.-K. Qu, and A. D. Keegan Phosphatidylcholine-Specific Phospholipase C Activity Is Necessary for the Activation of STAT6 J. Immunol., October 15, 2003; 171(8): 4203 - 4209. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Maccarrone, M. Bari, N. Battista, and A. Finazzi-Agro Estrogen stimulates arachidonoylethanolamide release from human endothelial cells and platelet activation Blood, December 1, 2002; 100(12): 4040 - 4048. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Perez-Andres, M. Fernandez-Rodriguez, M. Gonzalez, A. Zubiaga, A. Vallejo, I. Garcia, C. Matute, S. Pochet, J. P. Dehaye, M. Trueba, et al. Activation of phospholipase D-2 by P2X7 agonists in rat submandibular gland acini J. Lipid Res., August 1, 2002; 43(8): 1244 - 1255. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Barabe, G. Pare, M. J. G. Fernandes, S. G. Bourgoin, and P. H. Naccache Cholesterol-modulating Agents Selectively Inhibit Calcium Influx Induced by Chemoattractants in Human Neutrophils J. Biol. Chem., April 12, 2002; 277(16): 13473 - 13478. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Thibault, C. Burelout, D. Harbour, P. Borgeat, P. H. Naccache, and S. G. Bourgoin Occupancy of adenosine A2a receptors promotes fMLP-induced cyclic AMP accumulation in human neutrophils: impact on phospholipase D activity and recruitment of small GTPases to membranes J. Leukoc. Biol., February 1, 2002; 71(2): 367 - 377. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Frigeri and J. R. Apgar The Role of Actin Microfilaments in the Down-Regulation of the Degranulation Response in RBL-2H3 Mast Cells J. Immunol., February 15, 1999; 162(4): 2243 - 2250. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. S. Min, E.-G. Kim, and J. H. Exton Involvement of Tyrosine Phosphorylation and Protein Kinase C in the Activation of Phospholipase D by H2O2 in Swiss 3T3 Fibroblasts J. Biol. Chem., November 6, 1998; 273(45): 29986 - 29994. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. A. Fadool and I. B. Levitan Modulation of Olfactory Bulb Neuron Potassium Current by Tyrosine Phosphorylation J. Neurosci., August 15, 1998; 18(16): 6126 - 6137. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. C. Hool, L. M. Middleton, and R. D. Harvey Genistein Increases the Sensitivity of Cardiac Ion Channels to ß-Adrenergic Receptor Stimulation Circ. Res., July 13, 1998; 83(1): 33 - 42. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.-O. Mikalsen and O. Kaalhus Properties of Pervanadate and Permolybdate. CONNEXIN43, PHOSPHATASE INHIBITION, AND THIOL REACTIVITY AS MODEL SYSTEMS J. Biol. Chem., April 17, 1998; 273(16): 10036 - 10045. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. M. Facchinetti, R. Boland, and A. R. de Boland Calcitriol transmembrane signalling: regulation of rat muscle phospholipase D activity J. Lipid Res., January 1, 1998; 39(1): 197 - 204. [Abstract] [Full Text]
|
|
|
|
|
|
T. C. Holmes, K. Berman, J. E. Swartz, D. Dagan, and I. B. Levitan Expression of Voltage-Gated Potassium Channels Decreases Cellular Protein Tyrosine Phosphorylation J. Neurosci., December 1, 1997; 17(23): 8964 - 8974. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Marcil, D. Harbour, P. H. Naccache, and S. Bourgoin Human Phospholipase D1 Can Be Tyrosine-phosphorylated in HL-60 Granulocytes J. Biol. Chem., August 15, 1997; 272(33): 20660 - 20664. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Natarajan, W. M. Scribner, and S. Vepa Phosphatase Inhibitors Potentiate 4-Hydroxynonenal-induced Phospholipase D Activation in Vascular Endothelial Cells Am. J. Respir. Cell Mol. Biol., August 1, 1997; 17(2): 251 - 259. [Abstract] [Full Text]
|
|
|
|
 |
|
 M. Mietus-Snyder, A. Friera, C. K. Glass, and R. E. Pitas Regulation of Scavenger Receptor Expression in Smooth Muscle Cells by Protein Kinase C: A Role for Oxidative Stress Arterioscler. Thromb. Vasc. Biol., May 1, 1997; 17(5): 969 - 978. [Abstract] [Full Text]
|
|
|
|
 |
|
 A. Cadène, F. Grigorescu, J.-J. Serrano, and G. Cros Characterization of Vanadyl Sulfate Effect on Vascular Contraction: Roles of Calcium and Tyrosine Phosphorylation J. Pharmacol. Exp. Ther., April 1, 1997; 281(1): 491 - 498. [Abstract] [Full Text]
|
|
|
|
|
|
S. R. Yan and G. Berton Regulation of Src Family Tyrosine Kinase Activities in Adherent Human Neutrophils. EVIDENCE THAT REACTIVE OXYGEN INTERMEDIATES PRODUCED BY ADHERENT NEUTROPHILS INCREASE THE ACTIVITY OF THE p58c-fgr AND p53/56lyn TYROSINE KINASES J. Biol. Chem., September 20, 1996; 271(38): 23464 - 23471. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. H. Brumell, A. L. Burkhardt, J. B. Bolen, and S. Grinstein Endogenous Reactive Oxygen Intermediates Activate Tyrosine Kinases in Human Neutrophils J. Biol. Chem., January 19, 1996; 271(3): 1455 - 1461. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. J. Haque, V. Flati, A. Deb, and B. R. G. Williams Roles of Protein-tyrosine Phosphatases in Stat1alpha-mediated Cell Signaling J. Biol. Chem., October 27, 1995; 270(43): 25709 - 25714. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Lopez, D. J. Burns, and J. D. Lambeth Regulation of Phospholipase D by Protein Kinase C in Human Neutrophils J. Biol. Chem., August 18, 1995; 270(33): 19465 - 19472. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. E. Slack, J. Breu, M. A. Petryniak, K. Srivastava, and R. J. Wurtman Tyrosine Phosphorylation-dependent Stimulation of Amyloid Precursor Protein Secretion by the m3 Muscarinic Acetylcholine Receptor J. Biol. Chem., April 7, 1995; 270(14): 8337 - 8344. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |
