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J. Biol. Chem., Vol. 267, Issue 2, 922-925, Jan, 1992
A Gamian, M Beurret, F Michon, JR Brisson and HJ Jennings
Three different oligosaccharides were identified following mild acid
hydrolysis of the lipopolysaccharide obtained from Neisseria meningitidis
serotype 2 and their structures elucidated by combined chemical and
physical techniques. The use of 500 MHz 1H nmr in both one- and
two-dimensional modes as well as nuclear Overhauser effect experiments were
employed. To assist in the structural assignments the oligosaccharides were
also degraded by chemical and enzymatic procedures to smaller fragments.
The oligosaccharides were all triantennary nonasaccharides in which the
longest antenna terminates in lacto-N-neotetraose. Two of the
nonasaccharides (major components), not separable by column chromatography,
were distinguishable only by their different patterns of
phosphorylethanolamine substitution and the third minor component by the
absence of this substituent.
Structure of the L2 lipopolysaccharide core oligosaccharides of Neisseria meningitidis
Division of Biological Sciences, National Research Council of Canada, Ottawa, Ontario, Canada.
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