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J. Biol. Chem., Vol. 267, Issue 21, 14523-14526, Jul, 1992
CF Burant, J Takeda, E Brot-Laroche, GI Bell and NO Davidson
We recently reported that the glucose transporter isoform, GLUT5, is
expressed on the brush border membrane of human small intestinal
enterocytes (Davidson, N. O., Hausman, A. M. L., Ifkovits, C. A., Buse, J.
B., Gould, G. W., Burant, C. F., and Bell, G. I. (1992) Am. J. Physiol.
262, C795-C800). To define its role in sugar transport, human GLUT5 was
expressed in Xenopus oocytes and its substrate specificity and kinetic
properties determined. GLUT5 exhibits selectivity for fructose transport,
as determined by inhibition studies, with a Km of 6 mM. In addition,
fructose transport by GLUT5 is not inhibited by cytochalasin B, a
competitive inhibitor of facilitative glucose transporters. RNA and protein
blotting studies showed the presence of high levels of GLUT5 mRNA and
protein in human testis and spermatozoa, and immunocytochemical studies
localize GLUT5 to the plasma membrane of mature spermatids and spermatozoa.
The biochemical properties and tissue distribution of GLUT5 are consistent
with a physiological role for this protein as a fructose transporter.
Fructose transporter in human spermatozoa and small intestine is GLUT5
Department of Medicine, University of Chicago, Illinois 60637.
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