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J. Biol. Chem., Vol. 267, Issue 21, 14592-14597, Jul, 1992
G Stepien, A Torroni, AB Chung, JA Hodge and DC Wallace
The adenine nucleotide translocator (ANT) catalyzes the exchange of ADP and
ATP across the mitochondrial internal membrane. Its three isoforms, ANT1,
ANT2, and ANT3 are coded by differentially regulated nuclear genes. The
patterns of expression of these genes in human, bovine, and mouse tissue
are similar. ANT1 is highly expressed in heart and skeletal muscle and is
induced during myoblast differentiation. It is coordinately regulated with
the nuclear gene for the mitochondrial ATP synthase beta subunit, with
which it shares the positive muscle cis element, the OXBOX. ANT2 is either
absent or weakly expressed in all tissues. ANT3 is ubiquitously expressed
in all tissues, and its transcript level is proportional to the level of
oxidative metabolism. The tissue-specific expression of the ANT gene family
thus provides insight into the molecular basis of the differential reliance
of mammalian tissues on oxidative phosphorylation.
Differential expression of adenine nucleotide translocator isoforms in mammalian tissues and during muscle cell differentiation
Department of Genetics and Molecular Medicine, Emory University School of Medicine, Atlanta, Georgia 30322.
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