| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
J. Biol. Chem., Vol. 267, Issue 22, 15869-15874, 08, 1992
MJ Weickert and S Adhya
We describe a family of proteins which regulate transcription of inducible
genes in bacteria (GalR-LacI family). An alignment of the proteins in the
GalR-LacI family is presented in which these proteins show a very high
degree of similarity (60%) throughout the entire sequences. The homology is
greatest among the amino-terminal DNA binding domains. Since a portion of
the operator sequences occupied by these proteins is also conserved, a
similar DNA structure may be required for specific recognition of DNA by
members of the GalR-LacI family. Highly conserved motifs involved in
effector binding and oligomerization are also identified. This compilation
suggests a widespread conservation of these regulators among bacteria, and
have strong implications for further study of peptide motifs in domain
function, as well as pathways of protein evolution.
A family of bacterial regulators homologous to Gal and Lac repressors
Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  S. El Qaidi and J. Plumbridge Switching Control of Expression of ptsG from the Mlc Regulon to the NagC Regulon J. Bacteriol., July 1, 2008; 190(13): 4677 - 4686. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Brinkrolf, S. Ploger, S. Solle, I. Brune, S. S. Nentwich, A. T. Huser, J. Kalinowski, A. Puhler, and A. Tauch The LacI/GalR family transcriptional regulator UriR negatively controls uridine utilization of Corynebacterium glutamicum by binding to catabolite-responsive element (cre)-like sequences Microbiology, April 1, 2008; 154(4): 1068 - 1081. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Durante-Rodriguez, M. T. Zamarro, J. L. Garcia, E. Diaz, and M. Carmona New insights into the BzdR-mediated transcriptional regulation of the anaerobic catabolism of benzoate in Azoarcus sp. CIB Microbiology, January 1, 2008; 154(1): 306 - 316. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. E. Kaufman and J. Yother CcpA-Dependent and -Independent Control of Beta-Galactosidase Expression in Streptococcus pneumoniae Occurs via Regulation of an Upstream Phosphotransferase System-Encoding Operon J. Bacteriol., July 15, 2007; 189(14): 5183 - 5192. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. S. Franco, L. J. Mota, C. M. Soares, and I. de Sa-Nogueira Probing key DNA contacts in AraR-mediated transcriptional repression of the Bacillus subtilis arabinose regulon Nucleic Acids Res., July 9, 2007; 35(14): 4755 - 4766. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Puri-Taneja, M. Schau, Y. Chen, and F. M. Hulett Regulators of the Bacillus subtilis cydABCD Operon: Identification of a Negative Regulator, CcpA, and a Positive Regulator, ResD J. Bacteriol., May 1, 2007; 189(9): 3348 - 3358. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Horstmann, G. Seidel, L.-M. Aung-Hilbrich, and W. Hillen Residues His-15 and Arg-17 of HPr Participate Differently in Catabolite Signal Processing via CcpA J. Biol. Chem., January 12, 2007; 282(2): 1175 - 1182. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Deutscher, C. Francke, and P. W. Postma How Phosphotransferase System-Related Protein Phosphorylation Regulates Carbohydrate Metabolism in Bacteria Microbiol. Mol. Biol. Rev., December 1, 2006; 70(4): 939 - 1031. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Charoenpanich, A. Tani, N. Moriwaki, K. Kimbara, and F. Kawai Dual regulation of a polyethylene glycol degradative operon by AraC-type and GalR-type regulators in Sphingopyxis macrogoltabida strain 103. Microbiology, October 1, 2006; 152(Pt 10): 3025 - 3034. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. S. Franco, L. J. Mota, C. M. Soares, and I. de Sa-Nogueira Functional Domains of the Bacillus subtilis Transcription Factor AraR and Identification of Amino Acids Important for Nucleoprotein Complex Assembly and Effector Binding. J. Bacteriol., April 1, 2006; 188(8): 3024 - 3036. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Schumacher, G. Seidel, W. Hillen, and R. G. Brennan Phosphoprotein Crh-Ser46-P Displays Altered Binding to CcpA to Effect Carbon Catabolite Regulation J. Biol. Chem., March 10, 2006; 281(10): 6793 - 6800. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Chouikha, P. Germon, A. Bree, P. Gilot, M. Moulin-Schouleur, and C. Schouler A selC-Associated Genomic Island of the Extraintestinal Avian Pathogenic Escherichia coli Strain BEN2908 Is Involved in Carbohydrate Uptake and Virulence J. Bacteriol., February 1, 2006; 188(3): 977 - 987. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Oehler, S. Alberti, and B. Muller-Hill Induction of the lac promoter in the absence of DNA loops and the stoichiometry of induction Nucleic Acids Res., January 23, 2006; 34(2): 606 - 612. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Aleksandrzak-Piekarczyk, J. Kok, P. Renault, and J. Bardowski Alternative Lactose Catabolic Pathway in Lactococcus lactis IL1403 Appl. Envir. Microbiol., October 1, 2005; 71(10): 6060 - 6069. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Molenaar, F. Bringel, F. H. Schuren, W. M. de Vos, R. J. Siezen, and M. Kleerebezem Exploring Lactobacillus plantarum Genome Diversity by Using Microarrays J. Bacteriol., September 1, 2005; 187(17): 6119 - 6127. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. Ramos, M. Martinez-Bueno, A. J. Molina-Henares, W. Teran, K. Watanabe, X. Zhang, M. T. Gallegos, R. Brennan, and R. Tobes The TetR Family of Transcriptional Repressors Microbiol. Mol. Biol. Rev., June 1, 2005; 69(2): 326 - 356. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. L. Barragan, B. Blazquez, M. T. Zamarro, J. M. Mancheno, J. L. Garcia, E. Diaz, and M. Carmona BzdR, a Repressor That Controls the Anaerobic Catabolism of Benzoate in Azoarcus sp. CIB, Is the First Member of a New Subfamily of Transcriptional Regulators J. Biol. Chem., March 18, 2005; 280(11): 10683 - 10694. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Rigali, M. Schlicht, P. Hoskisson, H. Nothaft, M. Merzbacher, B. Joris, and F. Titgemeyer Extending the classification of bacterial transcription factors beyond the helix-turn-helix motif as an alternative approach to discover new cis/trans relationships Nucleic Acids Res., June 24, 2004; 32(11): 3418 - 3426. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. D. Esteban, K. Mahr, V. Monedero, W. Hillen, G. Perez-Martinez, and F. Titgemeyer Complementation of a {Delta}ccpA mutant of Lactobacillus casei with CcpA mutants affected in the DNA- and cofactor-binding domains Microbiology, March 1, 2004; 150(3): 613 - 620. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Tsujibo, M. Kosaka, S. Ikenishi, T. Sato, K. Miyamoto, and Y. Inamori Molecular Characterization of a High-Affinity Xylobiose Transporter of Streptomyces thermoviolaceus OPC-520 and Its Transcriptional Regulation J. Bacteriol., February 15, 2004; 186(4): 1029 - 1037. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Wang and H. K. Kuramitsu Control of Enzyme IIscr and Sucrose-6-Phosphate Hydrolase Activities in Streptococcus mutans by Transcriptional Repressor ScrR Binding to the cis-Active Determinants of the scr Regulon J. Bacteriol., October 1, 2003; 185(19): 5791 - 5799. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Chapuy-Regaud, A. D. Ogunniyi, N. Diallo, Y. Huet, J.-F. Desnottes, J. C. Paton, S. Escaich, and M.-C. Trombe RegR, a Global LacI/GalR Family Regulator, Modulates Virulence and Competence in Streptococcus pneumoniae Infect. Immun., May 1, 2003; 71(5): 2615 - 2625. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Langlois, S. Bourassa, G. G. Poirier, and C. Beaulieu Identification of Streptomyces coelicolor Proteins That Are Differentially Expressed in the Presence of Plant Material Appl. Envir. Microbiol., April 1, 2003; 69(4): 1884 - 1889. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Tsunedomi, H. Izu, T. Kawai, K. Matsushita, T. Ferenci, and M. Yamada The Activator of GntII Genes for Gluconate Metabolism, GntH, Exerts Negative Control of GntR-Regulated GntI Genes in Escherichia coli J. Bacteriol., March 15, 2003; 185(6): 1783 - 1795. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Fukami-Kobayashi, Y. Tateno, and K. Nishikawa Parallel Evolution of Ligand Specificity Between LacI/GalR Family Repressors and Periplasmic Sugar-Binding Proteins Mol. Biol. Evol., February 1, 2003; 20(2): 267 - 277. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. I. Trindade, V. R. Abratt, and S. J. Reid Induction of Sucrose Utilization Genes from Bifidobacterium lactis by Sucrose and Raffinose Appl. Envir. Microbiol., January 1, 2003; 69(1): 24 - 32. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Jahreis, L. Bentler, J. Bockmann, S. Hans, A. Meyer, J. Siepelmeyer, and J. W. Lengeler Adaptation of Sucrose Metabolism in the Escherichia coli Wild-Type Strain EC3132{dagger} J. Bacteriol., October 1, 2002; 184(19): 5307 - 5316. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Rigali, A. Derouaux, F. Giannotta, and J. Dusart Subdivision of the Helix-Turn-Helix GntR Family of Bacterial Regulators in the FadR, HutC, MocR, and YtrA Subfamilies J. Biol. Chem., April 5, 2002; 277(15): 12507 - 12515. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Swint-Kruse, C. Larson, B. M. Pettitt, and K. S. Matthews Fine-tuning function: Correlation of hinge domain interactions with functional distinctions between LacI and PurR Protein Sci., April 1, 2002; 11(4): 778 - 794. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. A. Marquez, S. Hasenbein, B. Koch, S. Fieulaine, S. Nessler, R. B. Russell, W. Hengstenberg, and K. Scheffzek Structure of the full-length HPr kinase/phosphatase from Staphylococcus xylosus at 1.95 A resolution: Mimicking the product/substrate of the phospho transfer reactions PNAS, March 19, 2002; 99(6): 3458 - 3463. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. J. Mota, L. M. Sarmento, and I. de Sa-Nogueira Control of the Arabinose Regulon in Bacillus subtilis by AraR In Vivo: Crucial Roles of Operators, Cooperativity, and DNA Looping J. Bacteriol., July 15, 2001; 183(14): 4190 - 4201. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. R. Moir-Blais, F. J. Grundy, and T. M. Henkin Transcriptional Activation of the Bacillus subtilis ackA Promoter Requires Sequences Upstream of the CcpA Binding Site J. Bacteriol., April 1, 2001; 183(7): 2389 - 2393. [Abstract] [Full Text]
|
|
|
|
|
|
E. E. Vaughan, P. T. C. van den Bogaard, P. Catzeddu, O. P. Kuipers, and W. M. de Vos Activation of Silent gal Genes in the lac-gal Regulon of Streptococcus thermophilus J. Bacteriol., February 15, 2001; 183(4): 1184 - 1194. [Abstract] [Full Text]
|
|
|
|
|
|
L. Swint-Kruse, C. R. Elam, J. W. Lin, D. R. Wycuff, and K. S. Matthews Plasticity of quaternary structure: Twenty-two ways to form a LacI dimer Protein Sci., February 1, 2001; 10(2): 262 - 276. [Abstract] [Full Text]
|
|
|
|
|
|
A. Hülsmann, R. Lurz, F. Scheffel, and E. Schneider Maltose and Maltodextrin Transport in the Thermoacidophilic Gram-Positive Bacterium Alicyclobacillus acidocaldarius Is Mediated by a High-Affinity Transport System That Includes a Maltose Binding Protein Tolerant to Low pH J. Bacteriol., November 15, 2000; 182(22): 6292 - 6301. [Abstract] [Full Text]
|
|
|
|
|
|
C. Leboeuf, L. Leblanc, Y. Auffray, and A. Hartke Characterization of the ccpA Gene of Enterococcus faecalis: Identification of Starvation-Inducible Proteins Regulated by CcpA J. Bacteriol., October 15, 2000; 182(20): 5799 - 5806. [Abstract] [Full Text]
|
|
|
|
|
|
J. Bogs and K. Geider Molecular Analysis of Sucrose Metabolism of Erwinia amylovora and Influence on Bacterial Virulence J. Bacteriol., October 1, 2000; 182(19): 5351 - 5358. [Abstract] [Full Text]
|
|
|
|
|
|
A. J. Turinsky, T. R. Moir-Blais, F. J. Grundy, and T. M. Henkin Bacillus subtilis ccpA Gene Mutants Specifically Defective in Activation of Acetoin Biosynthesis J. Bacteriol., October 1, 2000; 182(19): 5611 - 5614. [Abstract] [Full Text]
|
|
|
|
|
|
B. L. Swanson and A. N. Hamood Autoregulation of the Pseudomonas aeruginosa Protein PtxS Occurs through a Specific Operator Site within the ptxS Upstream Region J. Bacteriol., August 1, 2000; 182(15): 4366 - 4371. [Abstract] [Full Text]
|
|
|
|
|
|
E. d'Alençon and S. D. Ehrlich A Study of the CopF Repressor of Plasmid pAMbeta 1 by Phage Display J. Bacteriol., May 15, 2000; 182(10): 2973 - 2977. [Abstract] [Full Text]
|
|
|
|
|
|
E. Perez-Rueda and J. Collado-Vides The repertoire of DNA-binding transcriptional regulators in Escherichia coli K-12 Nucleic Acids Res., April 15, 2000; 28(8): 1838 - 1847. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. L. Meibom, B. H. Kallipolitis, R. H. Ebright, and P. Valentin-Hansen Identification of the Subunit of cAMP Receptor Protein (CRP) That Functionally Interacts with CytR in CRP-CytR-mediated Transcriptional Repression J. Biol. Chem., April 14, 2000; 275(16): 11951 - 11956. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Mahr, W. Hillen, and F. Titgemeyer Carbon Catabolite Repression in Lactobacillus pentosus: Analysis of the ccpA Region Appl. Envir. Microbiol., January 1, 2000; 66(1): 277 - 283. [Abstract] [Full Text]
|
|
|
|
|
|
E. Küster-Schöck, A. Wagner, U. Völker, and W. Hillen Mutations in Catabolite Control Protein CcpA Showing Glucose-Independent Regulation in Bacillus megaterium J. Bacteriol., December 15, 1999; 181(24): 7634 - 7638. [Abstract] [Full Text]
|
|
|
|
|
|
B. L. Swanson, J. A. Colmer, and A. N. Hamood The Pseudomonas aeruginosa Exotoxin A Regulatory Gene, ptxS: Evidence for Negative Autoregulation J. Bacteriol., August 15, 1999; 181(16): 4890 - 4895. [Abstract] [Full Text]
|
|
|
|
|
|
E. Küster, T. Hilbich, M. K. Dahl, and W. Hillen Mutations in Catabolite Control Protein CcpA Separating Growth Effects from Catabolite Repression J. Bacteriol., July 1, 1999; 181(13): 4125 - 4128. [Abstract] [Full Text]
|
|
|
|
|
|
S. A. Gavigan, T. Nguyen, N. Nguyen, and D. F. Senear Role of Multiple CytR Binding Sites on Cooperativity, Competition, and Induction at the Escherichia coli udp Promoter J. Biol. Chem., June 4, 1999; 274(23): 16010 - 16019. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Schlösser, J. Jantos, K. Hackmann, and H. Schrempf Characterization of the Binding Protein-Dependent Cellobiose and Cellotriose Transport System of the Cellulose Degrader Streptomyces reticuli Appl. Envir. Microbiol., June 1, 1999; 65(6): 2636 - 2643. [Abstract] [Full Text]
|
|
|
|
|
|
J. Strey, K. D. Wittchen, and F. Meinhardt Regulation of beta -Galactosidase Expression in Bacillus megaterium DSM319 by a XylS/AraC-Type Transcriptional Activator J. Bacteriol., May 15, 1999; 181(10): 3288 - 3292. [Abstract] [Full Text]
|
|
|
|
|
|
N. A. Spiridonov and D. B. Wilson Characterization and Cloning of CelR, a Transcriptional Regulator of Cellulase Genes from Thermomonospora fusca J. Biol. Chem., May 7, 1999; 274(19): 13127 - 13132. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Zalieckas, L. V. Wray Jr., and S. H. Fisher Expression of the Bacillus subtilis acsA Gene: Position and Sequence Context Affect cre-Mediated Carbon Catabolite Repression J. Bacteriol., December 15, 1998; 180(24): 6649 - 6654. [Abstract] [Full Text]
|
|
|
|
|
|
J. J. Ferretti Transcriptional Regulation of the Streptococcus mutans gal Operon by the GalR Repressor J. Bacteriol., November 1, 1998; 180(21): 5727 - 5732. [Abstract] [Full Text]
|
|
|
|
|
|
M. K. B. Berlyn Linkage Map of Escherichia coli K-12, Edition 10: The Traditional Map Microbiol. Mol. Biol. Rev., September 1, 1998; 62(3): 814 - 984. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G.-C. Shaw, H.-S. Kao, and C.-Y. Chiou Cloning, Expression, and Catabolite Repression of a Gene Encoding beta -Galactosidase of Bacillus megaterium ATCC 14581 J. Bacteriol., September 1, 1998; 180(17): 4734 - 4738. [Abstract] [Full Text]
|
|
|
|
|
|
J.-H. Kim, M. I. Voskuil, and G. H. Chambliss NADP, corepressor for the Bacillus catabolite control protein CcpA PNAS, August 4, 1998; 95(16): 9590 - 9595. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Marasco, L. Muscariello, M. Varcamonti, M. De Felice, and M. Sacco Expression of the bglH Gene of Lactobacillus plantarum Is Controlled by Carbon Catabolite Repression J. Bacteriol., July 1, 1998; 180(13): 3400 - 3404. [Abstract] [Full Text]
|
|
|
|
|
|
H. Xu, M. Moraitis, R. J. Reedstrom, and K. S. Matthews Kinetic and Thermodynamic Studies of Purine Repressor Binding to Corepressor and Operator DNA J. Biol. Chem., April 10, 1998; 273(15): 8958 - 8964. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Peekhaus and T. Conway Positive and Negative Transcriptional Regulation of the Escherichia coli Gluconate Regulon Gene gntT by GntR and the Cyclic AMP (cAMP)-cAMP Receptor Protein Complex J. Bacteriol., April 1, 1998; 180(7): 1777 - 1785. [Abstract] [Full Text]
|
|
|
|
|
|
S. Chauvaux, I. T. Paulsen, and M. H. Saier Jr. CcpB, a Novel Transcription Factor Implicated in Catabolite Repression in Bacillus subtilis J. Bacteriol., February 1, 1998; 180(3): 491 - 497. [Abstract] [Full Text]
|
|
|
|
|
|
C. Nieto, M. Espinosa, and A. Puyet The Maltose/Maltodextrin Regulon of Streptococcus pneumoniae. DIFFERENTIAL PROMOTER REGULATION BY THE TRANSCRIPTIONAL REPRESSOR MalR J. |
