| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
J. Biol. Chem., Vol. 267, Issue 33, 23439-23442, 11, 1992
L Kornberg, HS Earp, JT Parsons, M Schaller and RL Juliano
We have recently shown that changes in tyrosine phosphorylation of a
130-kDa protein(s) (pp130) may be involved in integrin signaling (Kornberg,
L., Earp, H.S., Turner, C., Prokop, and Juliano, R. L. (1991) Proc. Natl.
Acad. Sci. U.S.A. 88, 8392-8396). One component of the pp130 protein
complex reacts with an antibody generated against p125fak, which is a focal
contact-associated tyrosine kinase (Schaller, M.D., Borgman, C. A., Cobb,
B. S., Vines, R. R., Reynolds, A. B., and Parsons, J. T. (1992) Proc. Natl.
Acad. Sci. U.S.A. 89, 5192-5196). Both antibody-mediated integrin
clustering and adhesion of KB cells to fibronectin leads to increased
tyrosine phosphorylation of p125fak. The phosphorylation of p125fak is
coincident with adhesion of cells to fibronectin and is maximal prior to
cell spreading. Tyrosine phosphorylation of p125fak is induced when KB
cells are allowed to adhere to fibronectin, collagen type IV, or laminin,
but is not induced on polylysine. When KB cells are subjected to indirect
immunofluorescence microscopy, p125fak colocalizes with talin in focal
contacts. These data provide additional evidence that tyrosine kinases are
involved in integrin signaling.
Cell adhesion or integrin clustering increases phosphorylation of a focal adhesion-associated tyrosine kinase
Department of Pharmacology, University of North Carolina, Chapel Hill 27599.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  H.-B. Guo, M. Randolph, and M. Pierce Inhibition of a Specific N-Glycosylation Activity Results in Attenuation of Breast Carcinoma Cell Invasiveness-related Phenotypes: INHIBITION OF EPIDERMAL GROWTH FACTOR-INDUCED DEPHOSPHORYLATION OF FOCAL ADHESION KINASE J. Biol. Chem., July 27, 2007; 282(30): 22150 - 22162. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. P. Rodrigo, F. Dominguez, V. Suarez, M. Canel, P. Secades, and M. D. Chiara Focal Adhesion Kinase and E-Cadherin as Markers for Nodal Metastasis in Laryngeal Cancer Arch Otolaryngol Head Neck Surg, February 1, 2007; 133(2): 145 - 150. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. K. Quadri and J. Bhattacharya Resealing of endothelial junctions by focal adhesion kinase Am J Physiol Lung Cell Mol Physiol, January 1, 2007; 292(1): L334 - L342. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. N. MON, S. ITO, T. SENGA, and M. HAMAGUCHI FAK Signaling in Neoplastic Disorders: A Linkage between Inflammation and Cancer Ann. N.Y. Acad. Sci., November 1, 2006; 1086(1): 199 - 212. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Mehra, J. Fredrick, W. A. Petri Jr., S. Bhattacharya, and A. Bhattacharya Expression and Function of a Family of Transmembrane Kinases from the Protozoan Parasite Entamoeba histolytica Infect. Immun., September 1, 2006; 74(9): 5341 - 5351. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Le Boeuf, F. Houle, M. Sussman, and J. Huot Phosphorylation of Focal Adhesion Kinase (FAK) on Ser732 Is Induced by Rho-dependent Kinase and Is Essential for Proline-rich Tyrosine Kinase-2-mediated Phosphorylation of FAK on Tyr407 in Response to Vascular Endothelial Growth Factor Mol. Biol. Cell, August 1, 2006; 17(8): 3508 - 3520. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. M. Pirone, W. F. Liu, S. A. Ruiz, L. Gao, S. Raghavan, C. A. Lemmon, L. H. Romer, and C. S. Chen An inhibitory role for FAK in regulating proliferation: a link between limited adhesion and RhoA-ROCK signaling J. Cell Biol., July 17, 2006; 174(2): 277 - 288. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. N. Mon, H. Hasegawa, A. A. Thant, P. Huang, Y. Tanimura, T. Senga, and M. Hamaguchi A Role for Focal Adhesion Kinase Signaling in Tumor Necrosis Factor-{alpha}-Dependent Matrix Metalloproteinase-9 Production in a Cholangiocarcinoma Cell Line, CCKS1. Cancer Res., July 1, 2006; 66(13): 6778 - 6784. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Bryant, Q. Zheng, and K. Pumiglia Focal Adhesion Kinase Controls Cellular Levels of p27/Kip1 and p21/Cip1 through Skp2-Dependent and -Independent Mechanisms. Mol. Cell. Biol., June 1, 2006; 26(11): 4201 - 4213. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Canel, P. Secades, J.-P. Rodrigo, R. Cabanillas, A. Herrero, C. Suarez, and M.-D. Chiara Overexpression of Focal Adhesion Kinase in Head and Neck Squamous Cell Carcinoma Is Independent of fak Gene Copy Number. Clin. Cancer Res., June 1, 2006; 12(11): 3272 - 3279. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. S. Greenberg, A. M. Bernstein, M. Benezra, I. H. Gelman, L. Taliana, and S. K. Masur FAK-dependent regulation of myofibroblast differentiation FASEB J, May 1, 2006; 20(7): 1006 - 1008. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Hamadi, M. Bouali, M. Dontenwill, H. Stoeckel, K. Takeda, and P. Ronde Regulation of focal adhesion dynamics and disassembly by phosphorylation of FAK at tyrosine 397 J. Cell Sci., October 1, 2005; 118(19): 4415 - 4425. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W-B Zhong, Y-C Liang, C-Y Wang, T-C Chang, and W-S Lee Lovastatin suppresses invasiveness of anaplastic thyroid cancer cells by inhibiting Rho geranylgeranylation and RhoA/ROCK signaling Endocr. Relat. Cancer, September 1, 2005; 12(3): 615 - 629. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. De Frutos, M. Saura, M. Griera, F. J. Rivero-Vilches, C. Zaragoza, D. Rodriguez-Puyol, and M. Rodriguez-Puyol Differential Regulation of Soluble Guanylyl Cyclase Expression and Signaling by Collagens: Involvement of Integrin-Linked Kinase J. Am. Soc. Nephrol., September 1, 2005; 16(9): 2626 - 2635. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Frausin, V. Scarcia, M. Cocchietto, A. Furlani, B. Serli, E. Alessio, and G. Sava Free Exchange across Cells, and Echistatin-Sensitive Membrane Target for the Metastasis Inhibitor NAMI-A (Imidazolium trans-Imidazole Dimethyl Sulfoxide Tetrachlororuthenate) on KB Tumor Cells J. Pharmacol. Exp. Ther., April 1, 2005; 313(1): 227 - 233. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Ulanova, L. Puttagunta, M. Marcet-Palacios, M. Duszyk, U. Steinhoff, F. Duta, M.-K. Kim, Z. K. Indik, A. D. Schreiber, and A. D. Befus Syk tyrosine kinase participates in {beta}1-integrin signaling and inflammatory responses in airway epithelial cells Am J Physiol Lung Cell Mol Physiol, March 1, 2005; 288(3): L497 - L507. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Q. Ding, J. R. Grammer, M. A. Nelson, J.-L. Guan, J. E. Stewart Jr., and C. L. Gladson p27Kip1 and Cyclin D1 Are Necessary for Focal Adhesion Kinase Regulation of Cell Cycle Progression in Glioblastoma Cells Propagated in Vitro and in Vivo in the Scid Mouse Brain J. Biol. Chem., February 25, 2005; 280(8): 6802 - 6815. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. J. Kornberg, L. C. Shaw, P. E. Spoerri, S. Caballero, and M. B. Grant Focal Adhesion Kinase Overexpression Induces Enhanced Pathological Retinal Angiogenesis Invest. Ophthalmol. Vis. Sci., December 1, 2004; 45(12): 4463 - 4469. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Lunn and E. Rozengurt Hyperosmotic Stress Induces Rapid Focal Adhesion Kinase Phosphorylation at Tyrosines 397 and 577: ROLE OF Src FAMILY KINASES AND Rho FAMILY GTPases J. Biol. Chem., October 22, 2004; 279(43): 45266 - 45278. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. K. Sood, J. E. Coffin, G. B. Schneider, M. S. Fletcher, B. R. DeYoung, L. M. Gruman, D. M. Gershenson, M. D. Schaller, and M. J.C. Hendrix Biological Significance of Focal Adhesion Kinase in Ovarian Cancer: Role in Migration and Invasion Am. J. Pathol., October 1, 2004; 165(4): 1087 - 1095. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Wu, L. Chen, L. Cao, W. Sheng, and B. B. Yang Overexpression of the C-terminal PG-M/versican domain impairs growth of tumor cells by intervening in the interaction between epidermal growth factor receptor and {beta}1-integrin J. Cell Sci., May 1, 2004; 117(11): 2227 - 2237. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Itoh, T. Maeda, M. Shimada, S.-i. Aishima, K. Shirabe, S. Tanaka, and Y. Maehara Role of Expression of Focal Adhesion Kinase in Progression of Hepatocellular Carcinoma Clin. Cancer Res., April 15, 2004; 10(8): 2812 - 2817. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Q. Shi and D. Boettiger A Novel Mode for Integrin-mediated Signaling: Tethering Is Required for Phosphorylation of FAK Y397 Mol. Biol. Cell, October 1, 2003; 14(10): 4306 - 4315. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Laakko and R. L. Juliano Adhesion Regulation of Stromal Cell-derived Factor-1 Activation of ERK in Lymphocytes by Phosphatases J. Biol. Chem., August 22, 2003; 278(34): 31621 - 31628. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. SHEPPARD Functions of Pulmonary Epithelial Integrins: From Development to Disease Physiol Rev, July 1, 2003; 83(3): 673 - 686. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. T. Parsons Focal adhesion kinase: the first ten years J. Cell Sci., April 15, 2003; 116(8): 1409 - 1416. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Giese, R. Bjerkvig, M.E. Berens, and M. Westphal Cost of Migration: Invasion of Malignant Gliomas and Implications for Treatment J. Clin. Oncol., April 15, 2003; 21(8): 1624 - 1636. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. G. Puente and H. L. Ostergaard {beta}1/{beta}3 integrin ligation is uncoupled from ERK1/ERK2 activation in cytotoxic T lymphocytes J. Leukoc. Biol., March 1, 2003; 73(3): 391 - 398. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Reif, A. Lang, J. N. Lindquist, Y. Yata, E. Gabele, A. Scanga, D. A. Brenner, and R. A. Rippe The Role of Focal Adhesion Kinase-Phosphatidylinositol 3-Kinase-Akt Signaling in Hepatic Stellate Cell Proliferation and Type I Collagen Expression J. Biol. Chem., February 28, 2003; 278(10): 8083 - 8090. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. L. Lark, C. A. Livasy, B. Calvo, L. Caskey, D. T. Moore, X. Yang, and W. G. Cance Overexpression of Focal Adhesion Kinase in Primary Colorectal Carcinomas and Colorectal Liver Metastases: Immunohistochemistry and Real-Time PCR Analyses Clin. Cancer Res., January 1, 2003; 9(1): 215 - 222. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Kim and E. L. Feldman Insulin-like Growth Factor I Prevents Mannitol-induced Degradation of Focal Adhesion Kinase and Akt J. Biol. Chem., July 19, 2002; 277(30): 27393 - 27400. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Santoni, R. Lucciarini, C. Amantini, J. Jacobelli, E. Spreghini, P. Ballarini, M. Piccoli, and A. Gismondi Candida albicans Expresses a Focal Adhesion Kinase-Like Protein That Undergoes Increased Tyrosine Phosphorylation upon Yeast Cell Adhesion to Vitronectin and the EA.hy 926 Human Endothelial Cell Line Infect. Immun., July 1, 2002; 70(7): 3804 - 3815. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M.-H. Disatnik, S. C. Boutet, C. H. Lee, D. Mochly-Rosen, and T. A. Rando Sequential activation of individual PKC isozymes in integrin-mediated muscle cell spreading: a role for MARCKS in an integrin signaling pathway J. Cell Sci., May 15, 2002; 115(10): 2151 - 2163. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. E. Warchol Cell Density and N-Cadherin Interactions Regulate Cell Proliferation in the Sensory Epithelia of the Inner Ear J. Neurosci., April 1, 2002; 22(7): 2607 - 2616. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Belusa, O. Aizman, R. M. Andersson, and A. Aperia Changes in Na+-K+-ATPase activity influence cell attachment to fibronectin Am J Physiol Cell Physiol, February 1, 2002; 282(2): C302 - C309. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Datta, Q. Shi, and D. E. Boettiger Transformation of Chicken Embryo Fibroblasts by v-src Uncouples {beta}1 Integrin-Mediated Outside-in but Not Inside-out Signaling Mol. Cell. Biol., November 1, 2001; 21(21): 7295 - 7306. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. D. Zantek, J. Walker-Daniels, J. Stewart, R. K. Hansen, D. Robinson, H. Miao, B. Wang, H.-J. Kung, M. J. Bissell, and M. S. Kinch MCF-10A-NeoST: A New Cell System for Studying Cell-ECM and Cell-Cell Interactions in Breast Cancer Clin. Cancer Res., November 1, 2001; 7(11): 3640 - 3648. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Ayaki, K. Komatsu, M. Mukai, K. Murata, M. Kameyama, S. Ishiguro, J. Miyoshi, M. Tatsuta, and H. Nakamura Reduced Expression of Focal Adhesion Kinase in Liver Metastases Compared with Matched Primary Human Colorectal Adenocarcinomas Clin. Cancer Res., October 1, 2001; 7(10): 3106 - 3112. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Lu, G. Jiang, P. Blume-Jensen, and T. Hunter Epidermal Growth Factor-Induced Tumor Cell Invasion and Metastasis Initiated by Dephosphorylation and Downregulation of Focal Adhesion Kinase Mol. Cell. Biol., June 15, 2001; 21(12): 4016 - 4031. [Abstract] [Full Text]
|
|
|
|
 |
|
 L. M. Gleeson, C. Chakraborty, T. McKinnon, and P. K. Lala Insulin-Like Growth Factor-Binding Protein 1 Stimulates Human Trophoblast Migration by Signaling through {{alpha}}5{beta}1 Integrin via Mitogen-Activated Protein Kinase Pathway J. Clin. Endocrinol. Metab., June 1, 2001; 86(6): 2484 - 2493. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. D. Tang and S. J. Gunst Depletion of focal adhesion kinase by antisense depresses contractile activation of smooth muscle Am J Physiol Cell Physiol, April 1, 2001; 280(4): C874 - C883. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Scholle, K. M. Bendt, and N. Raab-Traub Epstein-Barr Virus LMP2A Transforms Epithelial Cells, Inhibits Cell Differentiation, and Activates Akt J. Virol., November 15, 2000; 74(22): 10681 - 10689. [Abstract] [Full Text]
|
|
|
|
 |
|
 K. G. Franchini, A. S. Torsoni, P. H. A. Soares, and M. J. A. Saad Early Activation of the Multicomponent Signaling Complex Associated With Focal Adhesion Kinase Induced by Pressure Overload in the Rat Heart Circ. Res., September 29, 2000; 87(7): 558 - 565. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Cooley, J. M. Broome, C. Ohngemach, L. H. Romer, and M. D. Schaller Paxillin Binding Is Not the Sole Determinant of Focal Adhesion Localization or Dominant-Negative Activity of Focal Adhesion Kinase/Focal Adhesion Kinase-related Nonkinase Mol. Biol. Cell, September 1, 2000; 11(9): 3247 - 3263. [Abstract] [Full Text]
|
|
|
|
|
|
G. Müller, S. Wied, and W. Frick Cross Talk of pp125FAK and pp59Lyn Non-Receptor Tyrosine Kinases to Insulin-Mimetic Signaling in Adipocytes Mol. Cell. Biol., July 1, 2000; 20(13): 4708 - 4723. [Abstract] [Full Text]
|
|
|
|
|
|
W. G. Cance, J. E. Harris, M. V. Iacocca, E. Roche, X. Yang, J. Chang, S. Simkins, and L. Xu Immunohistochemical Analyses of Focal Adhesion Kinase Expression in Benign and Malignant Human Breast and Colon Tissues: Correlation with Preinvasive and Invasive Phenotypes Clin. Cancer Res., June 1, 2000; 6(6): 2417 - 2423. [Abstract] [Full Text]
|
|
|
|
|
|
Y. Zaffran, S. C. Meyer, E. Negrescu, K. B. Reddy, and J. E. B. Fox Signaling across the Platelet Adhesion Receptor Glycoprotein Ib-IX Induces alpha IIbbeta 3 Activation Both in Platelets and a Transfected Chinese Hamster Ovary Cell System J. Biol. Chem., May 26, 2000; 275(22): 16779 - 16787. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D Wang, J. Grammer, C. Cobbs, J. Stewart, Z Liu, R Rhoden, T. Hecker, Q Ding, and C. Gladson p125 focal adhesion kinase promotes malignant astrocytoma cell proliferation in vivo J. Cell Sci., January 12, 2000; 113(23): 4221 - 4230. [Abstract] [PDF]
|
|
|
|
|
|
M. Wassler and B. Shur Clustering of cell surface (beta)1,4-galactosyltransferase I induces transient tyrosine phosphorylation of focal adhesion kinase and loss of stress fibers J. Cell Sci., January 1, 2000; 113(2): 237 - 245. [Abstract] [PDF]
|
|
|
|
|
|
M.-H. Disatnik and T. A. Rando Integrin-mediated Muscle Cell Spreading. THE ROLE OF PROTEIN KINASE C IN OUTSIDE-IN AND INSIDE-OUT SIGNALING AND EVIDENCE OF INTEGRIN CROSS-TALK J. Biol. Chem., November 5, 1999; 274(45): 32486 - 32492. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Tamura, J. Gu, H. Tran, and K. M. Yamada PTEN Gene and Integrin Signaling in Cancer J Natl Cancer Inst, November 3, 1999; 91(21): 1820 - 1828. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. W. Renshaw, L. S. Price, and M. A. Schwartz Focal Adhesion Kinase Mediates the Integrin Signaling Requirement for Growth Factor Activation of MAP Kinase J. Cell Biol., November 1, 1999; 147(3): 611 - 618. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. D. Schaller, J. D. Hildebrand, and J. T. Parsons Complex Formation with Focal Adhesion Kinase: A Mechanism to Regulate Activity and Subcellular Localization of Src Kinases Mol. Biol. Cell, October 1, 1999; 10(10): 3489 - 3505. [Abstract] [Full Text]
|
|
|
|
|
|
J. D. Owen, P. J. Ruest, D. W. Fry, and S. K. Hanks Induced Focal Adhesion Kinase (FAK) Expression in FAK-Null Cells Enhances Cell Spreading and Migration Requiring Both Auto- and Activation Loop Phosphorylation Sites and Inhibits Adhesion-Dependent Tyrosine Phosphorylation of Pyk2 Mol. Cell. Biol., July 1, 1999; 19(7): 4806 - 4818. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Wojciak-Stothard, L. Williams, and A. J. Ridley Monocyte Adhesion and Spreading on Human Endothelial Cells Is Dependent on Rho-regulated Receptor Clustering J. Cell Biol., June 14, 1999; 145(6): 1293 - 1307. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Scholle, R. Longnecker, and N. Raab-Traub Epithelial Cell Adhesion to Extracellular Matrix Proteins Induces Tyrosine Phosphorylation of the Epstein-Barr Virus Latent Membrane Protein 2: a Role for C-Terminal Src Kinase J. Virol., June 1, 1999; 73(6): 4767 - 4775. [Abstract] [Full Text]
|
|
|
|
|
|
M. S. Goligorsky, H. Abedi, E. Noiri, A. Takhtajan, S. Lense, V. Romanov, and I. Zachary Nitric oxide modulation of focal adhesions in endothelial cells Am J Physiol Cell Physiol, June 1, 1999; 276(6): C1271 - C1281. [Abstract] [Full Text] [PDF]
|
