| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
J. Biol. Chem., Vol. 267, Issue 4, 2282-2286, Feb, 1992
MA Phillips, BE Stewart and RH Rice
The gene for keratinocyte transglutaminase (TGK) spans 14 kilobase pairs
and contains 15 exons. Many features of the TGK gene are very similar, if
not identical, to those of the gene encoding the catalytic subunit of human
clotting factor XIII: they have the same number of exons, corresponding
introns always interrupt the coding region in the same phase of the codon,
and most exons are of similar size (10 or 15 are exactly the same size). In
these respects, the TGK and factor XIII catalytic subunit genes resemble
each other more than either resembles the gene for erythrocyte band 4.2, a
noncatalytic transglutaminase superfamily member. Exon II in both the TGK
and factor XIII genes encodes an amino-terminal extension of nonhomologous
sequence which in each protein confers a specialized function (membrane
anchorage or activation of cross-linking, respectively). This suggests that
the evolution of these genes included recruitment of a new exon to modify
the enzyme action. Southern blots of genomic DNA reveal the presence of a
TGK-like gene in birds, amphibians, and fish, but not in flies.
Genomic structure of keratinocyte transglutaminase. Recruitment of new exon for modified function
Department of Environmental Toxicology, University of California, Davis 95616-8588.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  B. Seetharam, S. Bose, and N. Li Cellular Import of Cobalamin (Vitamin B-12) J. Nutr., October 1, 1999; 129(10): 1761 - 1764. [Abstract] [Full Text]
|
|
|
|
 |
|
 A. Medvedev, N. A. Saunders, H. Matsuura, A. Chistokhina, and A. M. Jetten Regulation of the Transglutaminase I Gene. IDENTIFICATION OF DNA ELEMENTS INVOLVED IN ITS TRANSCRIPTIONAL CONTROL IN TRACHEOBRONCHIAL EPITHELIAL CELLS J. Biol. Chem., February 5, 1999; 274(6): 3887 - 3896. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Huber, V. C. Yee, N. Burri, E. Vikerfors, A. P. M. Lavrijsen, A. S. Paller, and D. Hohl Consequences of Seven Novel Mutations on the Expression and Structure of Keratinocyte Transglutaminase J. Biol. Chem., August 22, 1997; 272(34): 21018 - 21026. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Monsonego, Y. Shani, I. Friedmann, Y. Paas, O. Eizenberg, and M. Schwartz Expression of GTP-dependent and GTP-independent Tissue-type Transglutaminase in Cytokine-treated Rat Brain Astrocytes J. Biol. Chem., February 7, 1997; 272(6): 3724 - 3732. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-H. Lee, S.-I. Jang, J.-M. Yang, N. G. Markova, and P. M. Steinert The Proximal Promoter of the Human Transglutaminase 3 Gene J. Biol. Chem., February 23, 1996; 271(8): 4561 - 4568. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.-Y. Kim, S.-I. Chung, and P. M. Steinert Highly Active Soluble Processed Forms of the Transglutaminase 1 Enzyme in Epidermal Keratinocytes J. Biol. Chem., July 28, 1995; 270(30): 18026 - 18035. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M Huber, I Rettler, K Bernasconi, E Frenk, S. Lavrijsen, M Ponec, A Bon, S Lautenschlager, D. Schorderet, and D Hohl Mutations of keratinocyte transglutaminase in lamellar ichthyosis Science, January 27, 1995; 267(5197): 525 - 528. [Abstract] [PDF]
|
|
|
|
|
|
P. Grenard, M. K. Bates, and D. Aeschlimann Evolution of Transglutaminase Genes: Identification of a Transglutaminase Gene Cluster on Human Chromosome 15q15. STRUCTURE OF THE GENE ENCODING TRANSGLUTAMINASE X AND A NOVEL GENE FAMILY MEMBER, TRANSGLUTAMINASE Z J. Biol. Chem., August 24, 2001; 276(35): 33066 - 33078. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |
