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J. Biol. Chem., Vol. 268, Issue 12, 8640-8644, Apr, 1993
B Mlinar, BA Biagi and JJ Enyeart
Adrenocorticotropic hormone (ACTH) and angiotensin II (AII) are peptides
that regulate the production of steroid hormones by cells of the adrenal
cortex. The cellular mechanisms linking these peptides to corticosteroid
hormone secretion are not understood. In patch clamp recordings from bovine
adrenal zona fasciculata (AZF) cells, we have identified a novel cholera
toxin-sensitive K+ current (IAC), which is potently inhibited by both ACTH
and AII with respective EC50 values of 4.5 and 145 pM. These two peptides
depolarize AZF cells with a temporal pattern and potency that parallels the
inhibition of IAC. With the discovery of IAC, we have identified a common
molecular target for both ACTH and AII. The convergent inhibition of IAC by
these two peptides suggests a mechanism whereby biochemical signals
originating at the cell membrane can be transduced to
depolarization-dependent Ca2+ entry and steroid hormone secretion.
A novel K+ current inhibited by adrenocorticotropic hormone and angiotensin II in adrenal cortical cells
Department of Pharmacology, Ohio State University, College of Medicine, Columbus 43210-1239.
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