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J. Biol. Chem., Vol. 268, Issue 16, 11482-11485, 06, 1993
MK Webster, L Goya and GL Firestone
Serine/threonine protein kinases are important regulators of diverse
cellular processes including metabolism, proliferation, and
differentiation. We have previously identified the cDNA for a 49-kDa
serine/threonine kinase, designated sgk, which is transcriptionally
responsive to glucocorticoid hormones and serum in epithelial cells. We
report here that sgk expression is also rapidly induced by dexamethasone or
serum in Rat2 fibroblasts. Nuclear run-on and Northern blot analysis
revealed that the induction of sgk mRNA is an immediate- early
transcriptional response to serum stimulation of quiescent fibroblasts,
which occurs just after the peak in c-jun transcription. In contrast to the
glucocorticoid-stimulated sgk expression in Rat2 fibroblasts, the
transcriptional induction of sgk by serum was transient and sgk transcripts
decayed with a particularly rapid half- life of 20 min. The rapid turnover
of sgk, in combination with its immediate-early transcriptional response to
serum, suggests a novel mechanism for responding to mitogenic signals
during G0 to S transition and entry into the cell cycle.
Immediate-early transcriptional regulation and rapid mRNA turnover of a putative serine/threonine protein kinase
Department of Molecular and Cell Biology, University of California, Berkeley 94720.
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