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J. Biol. Chem., Vol. 268, Issue 20, 14678-14681, 07, 1993
GF Vile and RM Tyrrell
Heme oxygenase-1 mRNA levels increase following exposure of many mammalian
cell lines to oxidative stress such as ultraviolet A (UVA) irradiation.
Here we demonstrate a 4-fold increase in microsomal heme oxygenase activity
and a 40% decrease in microsomal heme content 14 h after treatment of human
skin fibroblasts (FEK4) with 250 kJ m-2 of UVA radiation. Paralleling this
was a 2-fold increase in ferritin levels that was sustained for at least 46
h after UVA irradiation. Treatment of fibroblasts with the iron chelating
agent desferrioxamine, after the UVA-dependent induction of heme oxygenase,
prevented the increase in ferritin levels. Treatment of fibroblasts with
Sn-protoporphyrin IX (an inhibitor of heme oxygenase) also prevented the
effect of UVA radiation on ferritin levels. Thus we conclude that the
effect of UVA radiation on ferritin levels is via the heme
oxygenase-dependent release of iron from endogenous heme sources. We
propose that the increase in ferritin that follows UVA irradiation would
decrease intracellular free iron such that iron-catalyzed free radical
reactions would be restricted during periods of subsequent oxidative
stress.
Oxidative stress resulting from ultraviolet A irradiation of human skin fibroblasts leads to a heme oxygenase-dependent increase in ferritin
Swiss Institute for Experimental Cancer Research, Lausanne.
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