| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
J. Biol. Chem., Vol. 268, Issue 29, 21875-21882, Oct, 1993
SE Barbour and EA Dennis
Macrophage-like P388D1 cells release [3H]arachidonic acid and produce
prostaglandin E2 (PGE2) upon stimulation with bacterial lipopolysaccharide
(LPS) and platelet-activating factor (PAF). To determine whether group II
phospholipase A2 (PLA2) is involved in this release, we treated P388D1
cells with antisense inhibitors specific for group II PLA2 RNA. Treatment
with oligonucleotide ASGII decreased PLA2 activity in P388D1 cell
homogenates by approximately 60% and reduced the release of [3H]arachidonic
acid and PGE2 from activated cells to nearly resting cell levels. The
inhibition by antisense oligonucleotide ASGII was blocked when its sense
complement, SGII, was included in the incubation mixture. Stably
transfected P388D1 cells expressing an antisense construct for group II
PLA2 also produced reduced quantities of PGE2 in response to LPS and PAF.
These data suggest that prostaglandin production by activated P388D1 cells
involves phospholipid hydrolysis by group II PLA2. Oligonucleotide ASGII
also blocked the appearance of a heparin-releasable group II PLA2 in the
culture supernatants of P388D1 cells. The disappearance of this protein
correlated with reduced PGE2 production by activated cells, indicating that
an extracellular heparin-associated pool of group II PLA2 is involved in
prostaglandin production by P388D1 cells.
Antisense inhibition of group II phospholipase A2 expression blocks the production of prostaglandin E2 by P388D1 cells
Department of Chemistry, University of California at San Diego, La Jolla 92093-0601.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  S. G. Payne, C. A. Oskeritzian, R. Griffiths, P. Subramanian, S. E. Barbour, C. E. Chalfant, S. Milstien, and S. Spiegel The immunosuppressant drug FTY720 inhibits cytosolic phospholipase A2 independently of sphingosine-1-phosphate receptors Blood, February 1, 2007; 109(3): 1077 - 1085. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Al-Darmaki, K. Knightshead, Y. Ishihara, A. Best, H. A. Schenkein, J. G. Tew, and S. E. Barbour Delineation of the Role of Platelet-Activating Factor in the Immunoglobulin G2 Antibody Response Clin. Vaccine Immunol., July 1, 2004; 11(4): 720 - 728. [Abstract] [Full Text]
|
|
|
|
 |
|
 M. A. Balboa, Y. Shirai, G. Gaietta, M. H. Ellisman, J. Balsinde, and E. A. Dennis Localization of Group V Phospholipase A2 in Caveolin-enriched Granules in Activated P388D1 Macrophage-like Cells J. Biol. Chem., November 28, 2003; 278(48): 48059 - 48065. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Al-Darmaki, H. A. Schenkein, J. G. Tew, and S. E. Barbour Differential Expression of Platelet-Activating Factor Acetylhydrolase in Macrophages and Monocyte-Derived Dendritic Cells J. Immunol., January 1, 2003; 170(1): 167 - 173. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. A. Carnevale and M. K. Cathcart Calcium-Independent Phospholipase A2 Is Required for Human Monocyte Chemotaxis to Monocyte Chemoattractant Protein 1 J. Immunol., September 15, 2001; 167(6): 3414 - 3421. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. N. Fonteh, G.-i. Atsumi, T. LaPorte, and F. H. Chilton Secretory Phospholipase A2 Receptor-Mediated Activation of Cytosolic Phospholipase A2 in Murine Bone Marrow-Derived Mast Cells J. Immunol., September 1, 2000; 165(5): 2773 - 2782. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Ishihara, J.-B. Zhang, S. M. Quinn, H. A. Schenkein, A. M. Best, S. E. Barbour, and J. G. Tew Regulation of Immunoglobulin G2 Production by Prostaglandin E2 and Platelet-Activating Factor Infect. Immun., March 1, 2000; 68(3): 1563 - 1568. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A Llorente, B van Deurs, O Garred, P Eker, and K Sandvig Apical endocytosis of ricin in MDCK cells is regulated by the cyclooxygenase pathway J. Cell Sci., January 4, 2000; 113(7): 1213 - 1221. [Abstract] [PDF]
|
|
|
|
|
|
M. A. Balboa, J. Balsinde, C. A. Johnson, and E. A. Dennis Regulation of Arachidonic Acid Mobilization in Lipopolysaccharide-activated P388D1 Macrophages by Adenosine Triphosphate J. Biol. Chem., December 17, 1999; 274(51): 36764 - 36768. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. V. BONVENTRE The 85-kD Cytosolic Phospholipase A2 Knockout Mouse: A NewTool for Physiology and Cell Biology J. Am. Soc. Nephrol., February 1, 1999; 10(2): 404 - 412. [Full Text]
|
|
|
|
 |
|
 M. E. Surette, N. Dallaire, N. Jean, S. Picard, and P. Borgeat Mechanisms of the priming effect of lipopolysaccharides on the biosynthesis of leukotriene B4 in chemotactic peptide-stimulated human neutrophils FASEB J, November 1, 1998; 12(14): 1521 - 1531. [Abstract] [Full Text]
|
|
|
|
 |
|
 J. Balsinde, M. A. Balboa, and E. A. Dennis Functional coupling between secretory phospholipase A2 and cyclooxygenase-2 and its regulation by cytosolic group IV phospholipase A2 PNAS, July 7, 1998; 95(14): 7951 - 7956. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Balboa, J. Balsinde, and E. A. Dennis Involvement of Phosphatidate Phosphohydrolase in Arachidonic Acid Mobilization in Human Amnionic WISH Cells J. Biol. Chem., March 27, 1998; 273(13): 7684 - 7690. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. T. Wong, K. Tran, G. N. Pierce, A. C. Chan, K. O, and P. C. Choy Lysophosphatidylcholine Stimulates the Release of Arachidonic Acid in Human Endothelial Cells J. Biol. Chem., March 20, 1998; 273(12): 6830 - 6836. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. R. Hundley, L. A. Marshall, W. C. Hubbard, and D. W. Macglashan Jr. Characteristics of Arachidonic Acid Generation in Human Basophils: Relationship Between the Effects of Inhibitors of Secretory Phospholipase A2 Activity and Leukotriene C4 Release J. Pharmacol. Exp. Ther., March 1, 1998; 284(3): 847 - 857. [Abstract] [Full Text]
|
|
|
|
|
|
M. M. Muthalif, I. F. Benter, M. R. Uddin, J. L. Harper, and K. U. Malik Signal Transduction Mechanisms Involved in Angiotensin-(1-7)-Stimulated Arachidonic Acid Release and Prostanoid Synthesis in Rabbit Aortic Smooth Muscle Cells J. Pharmacol. Exp. Ther., January 1, 1998; 284(1): 388 - 398. [Abstract] [Full Text]
|
|
|
|
|
|
T. Fournier, V. Fadok, and P. M. Henson Tumor Necrosis Factor-alpha Inversely Regulates Prostaglandin D2 and Prostaglandin E2 Production in Murine Macrophages. SYNERGISTIC ACTION OF CYCLIC AMP ON CYCLOOXYGENASE-2 EXPRESSION AND PROSTAGLANDIN E2 SYNTHESIS J. Biol. Chem., December 5, 1997; 272(49): 31065 - 31072. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. M. Anderson, A. Roshak, J. D. Winkler, M. McCord, and L. A. Marshall Cytosolic 85-kDa Phospholipase A2-mediated Release of Arachidonic Acid Is Critical for Proliferation of Vascular Smooth Muscle Cells J. Biol. Chem., November 28, 1997; 272(48): 30504 - 30511. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Balsinde, M. A. Balboa, and E. A. Dennis Antisense Inhibition of Group VI Ca2+-independent Phospholipase A2 Blocks Phospholipid Fatty Acid Remodeling in Murine P388D1 Macrophages J. Biol. Chem., November 14, 1997; 272(46): 29317 - 29321. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Balsinde, M. A. Balboa, and E. A. Dennis Inflammatory Activation of Arachidonic Acid Signaling in Murine P388D1 Macrophages via Sphingomyelin Synthesis J. Biol. Chem., August 15, 1997; 272(33): 20373 - 20377. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Murakami, H. Kuwata, Y. Amakasu, S. Shimbara, Y. Nakatani, G.-i. Atsumi, and I. Kudo Prostaglandin E2 Amplifies Cytosolic Phospholipase A2- and Cyclooxygenase-2-dependent Delayed Prostaglandin E2 Generation in Mouse Osteoblastic Cells. ENHANCEMENT BY SECRETORY PHOSPHOLIPASE A2 J. Biol. Chem., August 8, 1997; 272(32): 19891 - 19897. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Tischfield A Reassessment of the Low Molecular Weight Phospholipase A2 Gene Family in Mammals J. Biol. Chem., July 11, 1997; 272(28): 17247 - 17250. [Full Text] [PDF]
|
|
|
|
|
|
T. Wu, C. W. Angus, X.-L. Yao, C. Logun, and J. H. Shelhamer p11, a Unique Member of the S100 Family of Calcium-binding Proteins, Interacts with and Inhibits the Activity of the 85-kDa Cytosolic Phospholipase A2 J. Biol. Chem., July 4, 1997; 272(27): 17145 - 17153. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Q.-R. Chen, C. Miyaura, S. Higashi, M. Murakami, I. Kudo, S. Saito, T. Hiraide, Y. Shibasaki, and T. Suda Activation of Cytosolic Phospholipase A2 by Platelet-derived Growth Factor Is Essential for Cyclooxygenase-2-dependent Prostaglandin E2 Synthesis in Mouse Osteoblasts Cultured with Interleukin-1 J. Biol. Chem., February 28, 1997; 272(9): 5952 - 5958. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. A. Marshall, B. Bolognese, J. D. Winkler, and A. Roshak Depletion of Human Monocyte 85-kDa Phospholipase A2 Does Not Alter Leukotriene Formation J. Biol. Chem., January 10, 1997; 272(2): 759 - 765. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Balboa, J. Balsinde, M. V. Winstead, JayA. Tischfield, and EdwardA. Dennis Novel Group V Phospholipase A2 Involved in Arachidonic Acid Mobilization in Murine P388D1 Macrophages J. Biol. Chem., December 13, 1996; 271(50): 32381 - 32384. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Murakami, Y. Nakatani, and I. Kudo Type II Secretory Phospholipase A2 Associated with Cell Surfaces via C-terminal Heparin-binding Lysine Residues Augments Stimulus-initiated Delayed Prostaglandin Generation J. Biol. Chem., November 22, 1996; 271(47): 30041 - 30051. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. M. Muthalif, I. F. Benter, M. R. Uddin, and K. U. Malik Calcium/Calmodulin-dependent Protein Kinase IIalpha Mediates Activation of Mitogen-activated Protein Kinase and Cytosolic Phospholipase A2 in Norepinephrine-induced Arachidonic Acid Release in Rabbit Aortic Smooth Muscle Cells J. Biol. Chem., November 22, 1996; 271(47): 30149 - 30157. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. O. Bingham III, M. Murakami, H. Fujishima, J. E. Hunt, K. F. Austen, and J. P. Arm A Heparin-sensitive Phospholipase A2 and Prostaglandin Endoperoxide Synthase-2 Are Functionally Linked in the Delayed Phase of Prostaglandin D2 Generation in Mouse Bone Marrow-derived Mast Cells J. Biol. Chem., October 18, 1996; 271(42): 25936 - 25944. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. F. Taylor, J. D. Paulauskis, D. D. Weller, and L. Kobzik In Vitro Efficacy of Morpholino-modified Antisense Oligomers Directed against Tumor Necrosis Factor-alpha mRNA J. Biol. Chem., July 19, 1996; 271(29): 17445 - 17452. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.ús Balsinde and E. A. Dennis Distinct Roles in Signal Transduction for Each of the Phospholipase A(2) Enzymes Present in P388D(1) Macrophages J. Biol. Chem., March 22, 1996; 271(12): 6758 - 6765. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Locati, G. Lamorte, W. Luini, M. Introna, S. Bernasconi, A. Mantovani, and S. Sozzani Inhibition of Monocyte Chemotaxis to C-C Chemokines by Antisense Oligonucleotide for Cytosolic Phospholipase A(2) J. Biol. Chem., March 15, 1996; 271(11): 6010 - 6016. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Wijkander, J. T. O'Flaherty, A. B. Nixon, and R. L. Wykle 5-Lipoxygenase Products Modulate the Activity of the 85-kDa Phospholipase A(2) in Human Neutrophils J. Biol. Chem., November 3, 1995; 270(44): 26543 - 26549. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Laneuville, D. K. Breuer, N. Xu, Z. H. Huang, D. A. Gage, J. T. Watson, M. Lagarde, D. L. DeWitt, and W. L. Smith Fatty Acid Substrate Specificities of Human Prostaglandin-endoperoxide H Synthase-1 and -2 J. Biol. Chem., August 18, 1995; 270(33): 19330 - 19336. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Vial, M. Seorale-Pose, N. Havet, L. Molio, B. B. Vargaftig, and L. Touqui Expression of the Type-II Phospholipase A[IMAGE] in Alveolar Macrophages J. Biol. Chem., July 21, 1995; 270(29): 17327 - 17332. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Ancian, Gér. Lambeau, M.-G.èv. Mattéi, and M. Lazdunski The Human 180-kDa Receptor for Secretory Phospholipases A[IMAGE] J. Biol. Chem., April 14, 1995; 270(15): 8963 - 8970. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. J. Ackermann, K. Conde-Frieboes, and E. A. Dennis Inhibition of Macrophage Ca[IMAGE]-independent Phospholipase A(2) by Bromoenol Lactone and Trifluoromethyl Ketones J. Biol. Chem., January 6, 1995; 270(1): 445 - 450. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. K. Roshak, E. A. Capper, C. Stevenson, C. Eichman, and L. A. Marshall Human Calcium-independent Phospholipase A2 Mediates Lymphocyte Proliferation J. Biol. Chem., November 10, 2000; 275(46): 35692 - 35698. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. A. Ribardo, S. E. Crowe, K. R. Kuhl, J. W. Peterson, and A. K. Chopra Prostaglandin Levels in Stimulated Macrophages Are Controlled by Phospholipase A2-activating Protein and by Activation of Phospholipase C and D J. Biol. Chem., February 16, 2001; 276(8): 5467 - 5475. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Mizenina, E. Musatkina, Y. Yanushevich, A. Rodina, M. Krasilnikov, J. de Gunzburg, J. H. Camonis, A. Tavitian, and A. Tatosyan A Novel Group IIA Phospholipase A2 Interacts with v-Src Oncoprotein from RSV-transformed Hamster Cells J. Biol. Chem., August 31, 2001; 276(36): 34006 - 34012. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Balsinde, M. A. Balboa, and E. A. Dennis Identification of a Third Pathway for Arachidonic Acid Mobilization and Prostaglandin Production in Activated P388D1 Macrophage-like Cells J. Biol. Chem., July 14, 2000; 275(29): 22544 - 22549. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |
