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J. Biol. Chem., Vol. 268, Issue 32, 23824-23829, 11, 1993
SD Shapiro, DK Kobayashi and TJ Ley
Human alveolar macrophages have the capacity to degrade elastin. As an
approach to define proteinases responsible for this activity, we recently
cloned a murine macrophage elastase cDNA and demonstrated that it is a
member of the matrix metalloproteinase gene family (Shapiro, S. D.,
Griffin, G. L., Gilbert, D. J., Jenkins, N. A., Copeland, N. G., Welgus, H.
G., Senior, R. M., and Ley, T. J. (1992) J. Biol. Chem. 267, 4664-4671). We
now report that there is a human orthologue of murine macrophage
metalloelastase that we call human macrophage metalloelastase (HME). The
full-length HME cDNA spans 1.8 kilobases and contains an open reading frame
of 1410 base pairs; the predicted molecular mass of the HME proenzyme is 54
kDa. HME mRNA and protein were detected in human alveolar macrophages.
Similar to murine macrophage metalloelastase, HME readily undergoes NH2-
and COOH- terminal processing to a mature 22-kDa form. Both recombinant HME
expressed in Escherichia coli and native HME derived from human alveolar
macrophage-conditioned media degraded insoluble elastin. HME is a unique
human metalloproteinase that possesses elastolytic activity and is
expressed in alveolar macrophages; it is therefore a candidate molecule for
the causation of diseases characterized by damage to the extracellular
matrix.
Cloning and characterization of a unique elastolytic metalloproteinase produced by human alveolar macrophages
Department of Medicine, Jewish Hospital, Washington University Medical Center, St. Louis, Missouri 63110.
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P. J Barnes Genetics and pulmonary medicine bullet 9: Molecular genetics of chronic obstructive pulmonary disease Thorax, March 1, 1999; 54(3): 245 - 252. [Full Text]
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C. Munaut, T. Salonurmi, S. Kontusaari, P. Reponen, T. Morita, J.-M. Foidart, and K. Tryggvason Murine Matrix Metalloproteinase 9 Gene. 5'-UPSTREAM REGION CONTAINS CIS-ACTING ELEMENTS FOR EXPRESSION IN OSTEOCLASTS AND MIGRATING KERATINOCYTES IN TRANSGENIC MICE J. Biol. Chem., February 26, 1999; 274(9): 5588 - 5596. [Abstract] [Full Text] [PDF]
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L. A. Cornelius, L. C. Nehring, E. Harding, M. Bolanowski, H. G. Welgus, D. K. Kobayashi, R. A. Pierce, and S. D. Shapiro Matrix Metalloproteinases Generate Angiostatin: Effects on Neovascularization J. Immunol., December 15, 1998; 161(12): 6845 - 6852. [Abstract] [Full Text] [PDF]
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S.-i. Matsumoto, T. Kobayashi, M. Katoh, S. Saito, Y. Ikeda, M. Kobori, Y. Masuho, and T. Watanabe Expression and Localization of Matrix Metalloproteinase-12 in the Aorta of Cholesterol-Fed Rabbits : Relationship to Lesion Development Am. J. Pathol., July 1, 1998; 153(1): 109 - 119. [Abstract] [Full Text] [PDF]
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R. D. Hautamaki, D. K. Kobayashi, R. M. Senior, and S. D. Shapiro Requirement for Macrophage Elastase for Cigarette Smoke-Induced Emphysema in Mice Science, September 26, 1997; 277(5334): 2002 - 2004. [Abstract] [Full Text]
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