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J. Biol. Chem., Vol. 268, Issue 5, 3450-3455, 02, 1993
A Castellano, X Wei, L Birnbaumer and E Perez-Reyes
The skeletal muscle dihydropyridine receptor/Ca2+ channel consists of five
distinct subunits (alpha 1, alpha 2 delta, beta 1, and gamma). Homologous
alpha 1, alpha 2 delta, and beta 2 subunits are expressed in heart and
brain. The present study reports the cloning and expression of a third beta
subunit, beta 3, which is expressed predominantly in brain. Its open
reading frame encodes a protein with 484 amino acids with a predicted
molecular mass of 54,571 Da. Coexpression of beta 3 with a cardiac alpha 1
in Xenopus oocytes induces similar changes in Ca2+ channel activity as beta
1 and beta 2, that is, it increases peak currents, modulates the voltage
dependence of activation, and accelerates activation. In addition, beta 3
accelerates the rate of inactivation at positive test potentials.
Cloning and expression of a third calcium channel beta subunit
Department of Molecular Physiology, Baylor College of Medicine, Houston, Texas 77030.
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X. Wei, S. Pan, W. Lang, H. Kim, T. Schneider, E. Perez-Reyes, and L. Birnbaumer Molecular Determinants of Cardiac Ca[IMAGE] Channel Pharmacology J. Biol. Chem., November 10, 1995; 270(45): 27106 - 27111. [Abstract] [Full Text] [PDF]
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D. R. Witcher, M. D. Waard, H. Liu, M. Pragnell, and K. P. Campbell Association of Native Ca[IMAGE] Channel [IMAGE] Subunits with the [IMAGE][IMAGE] Subunit Interaction Domain J. Biol. Chem., July 28, 1995; 270(30): 18088 - 18093. [Abstract] [Full Text] [PDF]
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A. Koschak, D. Reimer, I. Huber, M. Grabner, H. Glossmann, J. Engel, and J. Striessnig alpha 1D (Cav1.3) Subunits Can Form L-type Ca2+ Channels Activating at Negative Voltages J. Biol. Chem., June 15, 2001; 276(25): 22100 - 22106. [Abstract] [Full Text] [PDF]
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H. J. Walter, T. McMahon, J. Dadgar, D. Wang, and R. O. Messing Ethanol Regulates Calcium Channel Subunits by Protein Kinase C delta -dependent and -independent Mechanisms J. Biol. Chem., August 11, 2000; 275(33): 25717 - 25722. [Abstract] [Full Text] [PDF]
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